『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.内田 大亮
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[継承]
2. (英) Kawamata Hitoshi (日) (読)
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[継承]
3.表原 文江
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4. (英) Nakashiro Koichi (日) (読)
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5. (英) Kimura-Yanagawa Tetsuo (日) (読)
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6. (英) Hino Satoshi (日) (読)
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7. (英) Begum Mila Nasima (日) (読)
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8. (英) Hoque MO (日) (読)
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9.吉田 秀夫
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10.佐藤 光信
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11. (英) Fujimori Takahiro (日) (読)
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題名 (必須): (英) Role of HGF/C-MET system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance  (日)    [継承]
副題 (任意):
要約 (任意): (英) We examined the role of the hepatocyte growth factor (HGF)/c-met system on invasion and metastasis of oral squamous cell carcinoma (SCC) cells. In monolayer culture, exogenous HGF marginally affected the growth of oral SCC cells (BHY, HN, IH) and human gingival epithelial cells (GE). In type I collagen matrix, however, HGF significantly enhanced the invasive growth of the cancer cells (p < 0.05). We detected the expression of c-met (HGF receptor) mRNA in all of the cancer cells, but not in human gingival fibroblasts (GF). Oral SCC cells did not secret HGF protein into the medium, but GF secreted a large amount of HGF protein (15 ng/ml). Furthermore, HGF markedly enhanced the migration of cancer cells in a Transwell invasion chamber. Then, we examined the serum levels of HGF in oral SCC patients, or HGF concentrations in oral cancer tissues. Serum levels of HGF in the patients were significantly higher than those in healthy volunteers (p < 0.05). After initial treatment, all of the tumor-free survivors showed a marked decline in the serum HGF levels. Furthermore, HGF concentrations in metastatic cancer tissues were significantly higher than those of non-metastatic cancer tissues and normal gingiva (p < 0.01). These results suggest that HGF plays an important role in invasion and metastasis of oral SCC cells as a paracrine factor, and an elevated HGF level in the cancer tissue can be a predictive marker for metastasis formation in patients with oral SCC.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Carcinoma, Squamous Cell (日) (読) [継承]
3. (英) Cattle (日) (読) [継承]
4.細胞分裂 (cell division) [継承]
5. (英) Cell Movement (日) (読) [継承]
6. (英) Fibroblast Growth Factor 2 (日) (読) [継承]
7. (英) Hepatocyte Growth Factor (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.免疫組織化学 (immunohistochemistry) [継承]
10. (英) Interleukin-1 (日) (読) [継承]
11. (英) Mouth Neoplasms (日) (読) [継承]
12. (英) Neoplasm Invasiveness (日) (読) [継承]
13. (英) Neoplasm Metastasis (日) (読) [継承]
14. (英) Proto-Oncogene Proteins c-met (日) (読) [継承]
15. (英) RNA, Messenger (日) (読) [継承]
16. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Cancer ([国際対ガン連合])
(pISSN: 0020-7136, eISSN: 1097-0215)

ISSN (任意): 0020-7136
ISSN: 0020-7136 (pISSN: 0020-7136, eISSN: 1097-0215)
Title: International journal of cancer
Title(ISO): Int. J. Cancer
Supplier: Union for International Cancer Control
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2001年 8月 15日 (平成 13年 8月 15日) [継承]
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DOI (任意): 10.1002/ijc.1368    (→Scopusで検索) [継承]
PMID (任意): 11477552    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000169853400005 [継承]
Scopus (任意): 2-s2.0-0035882576 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Uchida, Hitoshi Kawamata, Fumie Omotehara, Koichi Nakashiro, Tetsuo Kimura-Yanagawa, Satoshi Hino, Nasima Mila Begum, MO Hoque, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Role of HGF/C-MET system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance, International Journal of Cancer, Vol.93, No.4, 489-496, 2001.
欧文冊子 ● Daisuke Uchida, Hitoshi Kawamata, Fumie Omotehara, Koichi Nakashiro, Tetsuo Kimura-Yanagawa, Satoshi Hino, Nasima Mila Begum, MO Hoque, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Role of HGF/C-MET system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance, International Journal of Cancer, Vol.93, No.4, 489-496, 2001.

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