『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.内田 大亮
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[継承]
2. (英) Kawamata Hitoshi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Nakashiro Koichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4.表原 文江
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学籍番号 (推奨):
[継承]
5. (英) Hino Satoshi (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Hoque MO (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Begum Mila Nasima (日) (読)
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[継承]
8.吉田 秀夫
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[継承]
9.佐藤 光信
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学籍番号 (推奨):
[継承]
10. (英) Fujimori Takahiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines by up-regulation of tissue-type plasminogen activator and activation of pro-matrix metalloproteinases  (日)    [継承]
副題 (任意):
要約 (任意): (英) Retinoids inhibit the proliferation of several types of tumour cells, and are used for patients with several malignant tumours. In this study, we examined the effect of retinoic acids (RAs) on the invasive potentials of the oral squamous cell carcinoma (SCC) cells, BHY and HNt. BHY cells expressed all of retinoid nuclear receptors (RARalpha, beta, gamma, and RXRalpha) and cytoplasmic retinoic acid binding proteins (CRABP1 and CRABP2). HNt cells lacked the expression of RARbeta, but expressed other nuclear receptors and CRABPs. All-trans retinoic acid (ATRA) and 13-cis retinoic acid (13-cisRA) (10(-6)and 10(-7)M) inhibited the growth of the cells, but low-dose ATRA and 13-cisRA (10(-8)M) marginally affected the growth of the cells. Surprisingly, low-dose RAs enhanced the activity of tissue-type plasminogen activator (tPA), and activated pro-matrix metalloproteinases (proMMP2 and proMMP9). Activation of proMMP2 and proMMP9 was inhibited by aprotinin, a serine-proteinase, tPA inhibitor. Furthermore, low-dose RAs enhanced the in vitro invasiveness of BHY cells. These results indicate that low-dose RAs enhances the in vitro invasiveness of oral SCC cells via an activation of proMMP2 and proMMP9 probably mediated by the induction of tPA.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Agents (日) (読) [継承]
2. (英) Carcinoma, Squamous Cell (日) (読) [継承]
3.細胞分裂 (cell division) [継承]
4. (英) Collagenases (日) (読) [継承]
5. (英) Dose-Response Relationship, Drug (日) (読) [継承]
6. (英) Enzyme Activation (日) (読) [継承]
7. (英) Enzyme Precursors (日) (読) [継承]
8. (英) Gelatinases (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Isotretinoin (日) (読) [継承]
11. (英) Matrix Metalloproteinase 9 (日) (読) [継承]
12. (英) Matrix Metalloproteinases, Membrane-Associated (日) (読) [継承]
13. (英) Metalloendopeptidases (日) (読) [継承]
14. (英) Mouth Neoplasms (日) (読) [継承]
15. (英) Neoplasm Invasiveness (日) (読) [継承]
16. (英) Receptors, Retinoic Acid (日) (読) [継承]
17. (英) Tissue Inhibitor of Metalloproteinase-1 (日) (読) [継承]
18. (英) Tissue Inhibitor of Metalloproteinase-2 (日) (読) [継承]
19. (英) Tissue Plasminogen Activator (日) (読) [継承]
20. (英) Tretinoin (日) (読) [継承]
21. (英) Tumor Cells, Cultured (日) (読) [継承]
22. (英) Urokinase-Type Plasminogen Activator (日) (読) [継承]
発行所 (推奨):
誌名 (必須): British Journal of Cancer (British Empire Cancer Campaign/Cancer Research UK)
(pISSN: 0007-0920, eISSN: 1532-1827)

ISSN (任意): 0007-0920
ISSN: 0007-0920 (pISSN: 0007-0920, eISSN: 1532-1827)
Title: British journal of cancer
Title(ISO): Br. J. Cancer
Publisher: Nature Publishing Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 85 [継承]
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(必須): 122 128 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 7月 6日 (平成 13年 7月 6日) [継承]
URL (任意):
DOI (任意): 10.1054/bjoc.2001.1862    (→Scopusで検索) [継承]
PMID (任意): 11437413    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000169993500020 [継承]
Scopus (任意): 2-s2.0-17844396208 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) OtherID: PMC2363904  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Uchida, Hitoshi Kawamata, Koichi Nakashiro, Fumie Omotehara, Satoshi Hino, MO Hoque, Nasima Mila Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines by up-regulation of tissue-type plasminogen activator and activation of pro-matrix metalloproteinases, British Journal of Cancer, Vol.85, No.1, 122-128, 2001.
欧文冊子 ● Daisuke Uchida, Hitoshi Kawamata, Koichi Nakashiro, Fumie Omotehara, Satoshi Hino, MO Hoque, Nasima Mila Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines by up-regulation of tissue-type plasminogen activator and activation of pro-matrix metalloproteinases, British Journal of Cancer, Vol.85, No.1, 122-128, 2001.

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