『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=99704)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.内田 大亮
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学籍番号 (推奨):
[継承]
2.表原 文江
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学籍番号 (推奨):
[継承]
3. (英) Nakashiro Koichi (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Tateishi Yoshihisa (日) (読)
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5. (英) Hino Satoshi (日) (読)
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6. (英) Begum Mila Nasima (日) (読)
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7. (英) Fujimori Takahiro (日) (読)
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8. (英) Kawamata Hitoshi (日) (読)
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題名 (必須): (英) Posttranscriptional regulation of TSC-22 (TGF-β-stimulated clone-22) gene by TGF-β 1  (日)    [継承]
副題 (任意):
要約 (任意): (英) TSC-22 gene was composed of three exons and its length was approximately 5.5 kb including 2.9 kb promoter region. The transcription starting site was located at 7 and 29 bp downstream from TATA box. Promoter analysis revealed that 2146 bp of TSC-22 promoter was activated by several differentiation inducing drugs. Although originally TSC-22 was isolated as a TGF-beta-inducible gene, TSC-22 promoter was not activated by the enhanced TGF-beta signaling. We found 3 copies of the Shaw-Kamens sequence (AUUUA) in the human TSC-22 mRNA 3'-UTR and identified three proteins (40, 20, and 15 kDa) which bound to this. Only the 40 kDa protein-RNA complex was decreased by treatment with TGF-beta 1. Moreover, the TSC-22 mRNA 3'-UTR destabilized the heterologous luciferase mRNA, but the destabilization was recovered with TGF-beta 1. These observations suggest that up-regulation of TSC-22 mRNA by TGF-beta 1 is achieved by mRNA stabilization, but not by transcriptional activation.  (日)    [継承]
キーワード (推奨): 1. (英) 3' Untranslated Regions (日) (読) [継承]
2. (英) Base Sequence (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) HeLa Cells (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Molecular Sequence Data (日) (読) [継承]
7. (英) Promoter Regions, Genetic (日) (読) [継承]
8. (英) RNA Stability (日) (読) [継承]
9. (英) RNA, Messenger (日) (読) [継承]
10. (英) Repressor Proteins (日) (読) [継承]
11. (英) Response Elements (日) (読) [継承]
12. (英) Transcription Factors (日) (読) [継承]
13. (英) Transcription Initiation Site (日) (読) [継承]
14. (英) Transcriptional Activation (日) (読) [継承]
15. (英) Transforming Growth Factor beta (日) (読) [継承]
16. (英) Transforming Growth Factor beta1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem. Biophys. Res. Commun.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 305 [継承]
(必須): 4 [継承]
(必須): 846 856 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 6月 13日 (平成 15年 6月 13日) [継承]
URL (任意):
DOI (任意): 10.1016/S0006-291X(03)00854-4    (→Scopusで検索) [継承]
PMID (任意): 12767908    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000183578500011 [継承]
Scopus (任意): 2-s2.0-0038581167 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3-18-15 Kuramoto, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Article.DataBankList.DataBank.DataBankName: GENBANK  (日)    [継承]
3.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AF256226  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Uchida, Fumie Omotehara, Koichi Nakashiro, Yoshihisa Tateishi, Satoshi Hino, Nasima Mila Begum, Takahiro Fujimori and Hitoshi Kawamata : Posttranscriptional regulation of TSC-22 (TGF-β-stimulated clone-22) gene by TGF-β 1, Biochemical and Biophysical Research Communications, Vol.305, No.4, 846-856, 2003.
欧文冊子 ● Daisuke Uchida, Fumie Omotehara, Koichi Nakashiro, Yoshihisa Tateishi, Satoshi Hino, Nasima Mila Begum, Takahiro Fujimori and Hitoshi Kawamata : Posttranscriptional regulation of TSC-22 (TGF-β-stimulated clone-22) gene by TGF-β 1, Biochemical and Biophysical Research Communications, Vol.305, No.4, 846-856, 2003.

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