『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=99693EID:99693, Map:0, LastModified:2016年9月9日(金) 16:26:10, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[伊賀 弘起], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Almofti Ammar (日) (読)
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2.内田 大亮
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3. (英) Begum Mila Nasima (日) (読)
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4. (英) Tomizuka Yoshifumi (日) (読)
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5.伊賀 弘起 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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6.吉田 秀夫
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7.佐藤 光信
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題名 (必須): (英) The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have demonstrated the possibility that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system might be involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (SCC). In order to further clarify the role of the SDF-1/CXCR4 system in oral SCC, we examined the expression of CXCR4 and SDF-1 in biopsy specimens from 61 patients with oral SCC by means of immunohistochemistry, and investigated several clinicopathological factors, including age, sex, lymph node metastasis, invasion, recurrence and prognosis. The expression of CXCR4 and SDF-1 was observed in 57.3 and 11.4% of our subjects, respectively. Although we were unable to find a statistically significant association between the expression of SDF-1 and any clinicopathological factors, we did find a significant association between the expression of CXCR4 and lymph node metastasis (P=0.0417). Moreover, the mode of invasion (P=0.0002) and recurrence of the tumors (P=0.0185) were strongly associated with CXCR4 expression, and the CXCR4-positive group showed a significantly poorer prognosis than the CXCR4-negative group (P=0.0401). Recombinant SDF-1alpha stimulated in vitro invasiveness and scattering in CXCR4-expressing oral SCC cells, but the treatment did not affect the expression of matrix metalloproteinases or urokinase-type plasminogen activator. These results indicate that SDF-1/CXCR4 signaling in oral SCC cells might be involved in the diverse action of oral SCC, including invasion or micrometastasis at the primary site and lymph node metastasis.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Carcinoma, Squamous Cell (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Chemokine CXCL12 (日) (読) [継承]
5. (英) Chemokines, CXC (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Lymphatic Metastasis (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Middle Aged (日) (読) [継承]
11. (英) Mouth Neoplasms (日) (読) [継承]
12. (英) Neoplasm Invasiveness (日) (読) [継承]
13. (英) Receptors, CXCR4 (日) (読) [継承]
14. (英) Recurrence (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1019-6439
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int. J. Oncol.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2004年 7月 初日 (平成 16年 7月 初日) [継承]
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DOI (任意):
PMID (任意): 15201990    (→Scopusで検索) [継承]
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WOS (任意): 000222162400007 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ammar Almofti, Daisuke Uchida, Nasima Mila Begum, Yoshifumi Tomizuka, Hiroki Iga, Hideo Yoshida and Mitsunobu Sato : The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma, International Journal of Oncology, Vol.25, No.1, 65-71, 2004.
欧文冊子 ● Ammar Almofti, Daisuke Uchida, Nasima Mila Begum, Yoshifumi Tomizuka, Hiroki Iga, Hideo Yoshida and Mitsunobu Sato : The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma, International Journal of Oncology, Vol.25, No.1, 65-71, 2004.

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