『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.内田 大亮
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学籍番号 (推奨):
[継承]
2. (英) Begum Mila Nasima (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Almofti Ammar (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Nakashiro Koichi (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Kawamata Hitoshi (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Tateishi Yoshihisa (日) (読)
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学籍番号 (推奨):
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7. (英) Hamakawa Hiroyuki (日) (読)
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学籍番号 (推奨):
[継承]
8.吉田 秀夫
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学籍番号 (推奨):
[継承]
9.佐藤 光信
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma  (日)    [継承]
副題 (任意):
要約 (任意): (英) We examined the role of chemokine signaling on the lymph node metastasis of oral squamous cell carcinoma (SCC) using lymph node metastatic (HNt and B88) and nonmetastatic oral SCC cells. Of 13 kinds of chemokine receptors examined, only CXCR4 expression was up-regulated in HNt and B88 cells. CXCR4 ligand, stromal-cell-derived factor-1alpha (SDF-1alpha; CXCL12), induced characteristic calcium fluxes and chemotaxis only in CXCR4-expressing cells. CXCR4 expression in metastatic cancer tissue was significantly higher than that in nonmetastatic cancer tissue or normal gingiva. Although SDF-1alpha was undetectable in either oral SCC or normal epithelial cells, submandibular lymph nodes expressed the SDF-1alpha protein, mainly in the stromal cells, but occasionally in metastatic cancer cells. The conditioned medium from lymphatic stromal cells promoted the chemotaxis of B88 cells, which was blocked by the CXCR4 neutralization. SDF-1alpha rapidly activated extracellular signal-regulated kinase (ERK)1/2 and Akt/protein kinase B (PKB), and their synthetic inhibitors attenuated the chemotaxis by SDF-1alpha. SDF-1alpha also activated Src family kinases (SFKs), and its inhibitor PP1 diminished the SDF-1alpha-induced chemotaxis and activation of both ERK1/2 and Akt/PKB. These results indicate that SDF-1/CXCR4 signaling may be involved in the establishment of lymph node metastasis in oral SCC via activation of both ERK1/2 and Akt/PKB induced by SFKs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3.カルシウム (calcium) [継承]
4. (英) Carcinoma, Squamous Cell (日) (読) [継承]
5. (英) Cell Movement (日) (読) [継承]
6. (英) Chemokine CXCL12 (日) (読) [継承]
7. (英) Chemokines, CXC (日) (読) [継承]
8. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Lymphatic Metastasis (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred BALB C (日) (読) [継承]
13. (英) Mice, Nude (日) (読) [継承]
14. (英) Mitogen-Activated Protein Kinase 1 (日) (読) [継承]
15. (英) Mitogen-Activated Protein Kinase 3 (日) (読) [継承]
16. (英) Mitogen-Activated Protein Kinases (日) (読) [継承]
17. (英) Mouth Neoplasms (日) (読) [継承]
18.リン酸化 (phosphorylation) [継承]
19. (英) Precipitin Tests (日) (読) [継承]
20. (英) Protein-Serine-Threonine Kinases (日) (読) [継承]
21. (英) Proto-Oncogene Proteins (日) (読) [継承]
22. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
23. (英) Receptors, CXCR4 (日) (読) [継承]
24.シグナル伝達 (signal transduction) [継承]
発行所 (推奨):
誌名 (必須): Experimental Cell Research ([Academic Press])
(pISSN: 0014-4827, eISSN: 1090-2422)

ISSN (任意): 0014-4827
ISSN: 0014-4827 (pISSN: 0014-4827, eISSN: 1090-2422)
Title: Experimental cell research
Title(ISO): Exp. Cell Res.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 290 [継承]
(必須): 2 [継承]
(必須): 289 302 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 11月 1日 (平成 15年 11月 1日) [継承]
URL (任意):
DOI (任意): 10.1016/S0014-4827(03)00344-6    (→Scopusで検索) [継承]
PMID (任意): 14567988    (→Scopusで検索) [継承]
NAID (任意): 80016268266 [継承]
WOS (任意): 000186132500011 [継承]
Scopus (任意): 2-s2.0-0142121466 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3-18-15 Kuramoto, Tokushima 770-8504, Japan. daisuke@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Uchida, Nasima Mila Begum, Ammar Almofti, Koichi Nakashiro, Hitoshi Kawamata, Yoshihisa Tateishi, Hiroyuki Hamakawa, Hideo Yoshida and Mitsunobu Sato : Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma, Experimental Cell Research, Vol.290, No.2, 289-302, 2003.
欧文冊子 ● Daisuke Uchida, Nasima Mila Begum, Ammar Almofti, Koichi Nakashiro, Hitoshi Kawamata, Yoshihisa Tateishi, Hiroyuki Hamakawa, Hideo Yoshida and Mitsunobu Sato : Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma, Experimental Cell Research, Vol.290, No.2, 289-302, 2003.

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