『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=98521)

EID=98521EID:98521, Map:0, LastModified:2014年4月30日(水) 14:07:15, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[石丸 直澄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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学籍番号 (推奨):
[継承]
2. (英) Yanagi Kumiko (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Ogawa Kouichi (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Suda Takashi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Saito Ichiro (日) (読)
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学籍番号 (推奨):
[継承]
6.林 良夫
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Possible Role of Organ-Specific Autoantigen for Fas Ligand-Mediated Activation-Induced Cell Death in Murine Sjögren's Syndrome1  (日)    [継承]
副題 (任意):
要約 (任意): (英) Activation-induced cell death (AICD) is a well-known mechanism of peripheral T cell tolerance that depends upon an interaction between Fas and Fas ligand (FasL). In this study, we demonstrate that the administration of a soluble form of anti-FasL Ab, FLIM58, results in severe destructive autoimmune exocrinopathy in the murine model of human Sjögren's syndrome (SS), and we found that an organ-specific autoantigen may play an important role on down-modulation of AICD. A high titer of serum autoantibodies against 120-kDa alpha-fodrin autoantigen was detected in the FLIM58-treated mice, and splenic T cell culture supernatants contained high levels of IFN-gamma. In vitro T cell apoptosis assay indicated that FasL-mediated AICD is down-regulated by autoantigen stimulation in spleen cells from the murine SS model, but not from Fas-deficient MRL/lpr mice and FasL-deficient MRL/gld mice. FasL undergo metalloproteinase-mediated proteolytic processing in their extracellular domains, resulting in the release of soluble trimeric ligands (soluble FasL). We showed that the processing of soluble FasL occurs in autoantigen-specific CD4(+) T cells, and that a significant increase in expressions of metalloproteinase-9 mRNA was observed in spleen cells from SS model mice. These findings indicate that the increased generation of soluble FasL inhibits the normal AICD process, leading to the proliferation of effector CD4(+) T cells in the murine SS model.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Monoclonal (日) (読) [継承]
3. (英) Antigens, CD95 (日) (読) [継承]
4. (英) Apoptosis (日) (読) [継承]
5. (英) Autoantibodies (日) (読) [継承]
6. (英) Autoantigens (日) (読) [継承]
7. (英) Carrier Proteins (日) (読) [継承]
8. (英) Cells, Cultured (日) (読) [継承]
9. (英) Cytokines (日) (読) [継承]
10. (英) Fas Ligand Protein (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12. (英) Immunophenotyping (日) (読) [継承]
13. (英) Lymphocyte Activation (日) (読) [継承]
14. (英) Matrix Metalloproteinase 9 (日) (読) [継承]
15. (英) Membrane Glycoproteins (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Microfilament Proteins (日) (読) [継承]
18. (英) Models, Biological (日) (読) [継承]
19. (英) Sjogren's Syndrome (日) (読) [継承]
20. (英) Spleen (日) (読) [継承]
21. (英) T-Lymphocyte Subsets (日) (読) [継承]
22. (英) T-Lymphocytes (日) (読) [継承]
発行所 (推奨): The American Association of Immunologists [継承]
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 167 [継承]
(必須): 10 [継承]
(必須): 6031 6037 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 11月 15日 (平成 13年 11月 15日) [継承]
URL (任意): http://www.jimmunol.org/cgi/content/abstract/167/10/6031 [継承]
DOI (任意): 10.4049/jimmunol.167.10.6031    (→Scopusで検索) [継承]
PMID (任意): 11698484    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000172106400067 [継承]
Scopus (任意): 2-s2.0-0035889899 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Naozumi Ishimaru, Kumiko Yanagi, Kouichi Ogawa, Takashi Suda, Ichiro Saito and Yoshio Hayashi : Possible Role of Organ-Specific Autoantigen for Fas Ligand-Mediated Activation-Induced Cell Death in Murine Sjögren's Syndrome1, The Journal of Immunology, Vol.167, No.10, 6031-6037, 2001.
欧文冊子 ● Naozumi Ishimaru, Kumiko Yanagi, Kouichi Ogawa, Takashi Suda, Ichiro Saito and Yoshio Hayashi : Possible Role of Organ-Specific Autoantigen for Fas Ligand-Mediated Activation-Induced Cell Death in Murine Sjögren's Syndrome1, The Journal of Immunology, Vol.167, No.10, 6031-6037, 2001.

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