『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Inoue Hiroko (日) (読)
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[継承]
2. (英) Tsubota Kazuo (日) (読)
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[継承]
3. (英) Ono Masafumi (日) (読)
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[継承]
4. (英) Kizu Yasuhiro (日) (読)
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[継承]
5. (英) Mizuno Fumio (日) (読)
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[継承]
6. (英) Takada Kenzo (日) (読)
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[継承]
7. (英) Yamada Koichi (日) (読)
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[継承]
8. (英) Yanagi Kumiko (日) (読)
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[継承]
9.林 良夫
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[継承]
10. (英) Saito Ichiro (日) (読)
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[継承]
題名 (必須): (英) Possible Involvement of EBV-Mediated α-Fodrin Cleavage for Organ-Specific Autoantigen in Sjogren's Syndrome  (日)    [継承]
副題 (任意):
要約 (任意): (英) A cleavage product of alpha-fodrin may be an important organ-specific autoantigen in the pathogenesis of Sjogren's syndrome (SS), but the mechanisms of alpha-fodrin cleavage remain unclear. Since EBV has been implicated in the pathogenesis of SS, we determined whether EBV activation could induce the SS-specific 120-kDa autoantigen alpha-fodrin. ZEBRA mRNA expression, a marker for activation of the lytic cycle of EBV, was found in the salivary gland tissues from SS patients, but not in those from control individuals. ZEBRA-expressing lymphoid cells were also found in the SS glands in double-stained immunohistochemistry. Furthermore, a significant link between production of Abs against 120-kDa alpha-fodrin and reactivated EBV Ag was found in sera from patients with SS, but not in those from control individuals. EBV-activated lymphoid cells showed specific alpha-fodrin cleavage to the expected 120-kDa fragments in vitro. Pretreatment with caspase inhibitors inhibited cleavage of alpha-fodrin. Thus, an increase in apoptotic protease activities induced by EBV reactivation may be involved in the progression of alpha-fodrin proteolysis in the development of SS.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Chloromethyl Ketones (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (英) Aprotinin (日) (読) [継承]
4. (英) Autoantigens (日) (読) [継承]
5. (英) Carrier Proteins (日) (読) [継承]
6. (英) Caspases (日) (読) [継承]
7. (英) Cysteine Proteinase Inhibitors (日) (読) [継承]
8. (英) DNA-Binding Proteins (日) (読) [継承]
9. (英) Herpesvirus 4, Human (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Hydrolysis (日) (読) [継承]
12. (英) Leucine (日) (読) [継承]
13. (英) Leupeptins (日) (読) [継承]
14. (英) Microfilament Proteins (日) (読) [継承]
15.分子量 (molecular weight) [継承]
16. (英) Organ Specificity (日) (読) [継承]
17. (英) Pepstatins (日) (読) [継承]
18.シェーグレン症候群 (Sjögren's syndrome) [継承]
19. (英) Trans-Activators (日) (読) [継承]
20. (英) Tumor Cells, Cultured (日) (読) [継承]
21. (英) Viral Proteins (日) (読) [継承]
22. (英) Virus Activation (日) (読) [継承]
発行所 (推奨): The American Association of Immunologists [継承]
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 166 [継承]
(必須): 9 [継承]
(必須): 5801 5809 [継承]
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年月日 (必須): 西暦 2001年 5月 1日 (平成 13年 5月 1日) [継承]
URL (任意): http://www.jimmunol.org/cgi/content/abstract/166/9/5801 [継承]
DOI (任意):
PMID (任意): 11313424    (→Scopusで検索) [継承]
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WOS (任意): 000171906500058 [継承]
Scopus (任意): 2-s2.0-0035340982 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pathology, Tokushima University School of Dentistry, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroko Inoue, Kazuo Tsubota, Masafumi Ono, Yasuhiro Kizu, Fumio Mizuno, Kenzo Takada, Koichi Yamada, Kumiko Yanagi, Yoshio Hayashi and Ichiro Saito : Possible Involvement of EBV-Mediated α-Fodrin Cleavage for Organ-Specific Autoantigen in Sjogren's Syndrome, The Journal of Immunology, Vol.166, No.9, 5801-5809, 2001.
欧文冊子 ● Hiroko Inoue, Kazuo Tsubota, Masafumi Ono, Yasuhiro Kizu, Fumio Mizuno, Kenzo Takada, Koichi Yamada, Kumiko Yanagi, Yoshio Hayashi and Ichiro Saito : Possible Involvement of EBV-Mediated α-Fodrin Cleavage for Organ-Specific Autoantigen in Sjogren's Syndrome, The Journal of Immunology, Vol.166, No.9, 5801-5809, 2001.

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