『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=98415EID:98415, Map:0, LastModified:2018年2月9日(金) 16:43:59, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.情報統合医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.中村 教泰
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2. (英) Tsumoto Kouhei (日) (読)
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3.石村 和敬
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4. (英) Kumagai Izumi (日) (読)
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題名 (必須): (英) The effect of an agglutogen on virus infection: biotinylated filamentous phages and avidin as a model.  (日)    [継承]
副題 (任意):
要約 (任意): (英) To address the effect of an agglutogen on virus infection, we studied the avidin-associated inhibition of infection by biotinylated M13 phages (BIO-phages). Microscopic observation of mixtures of BIO-phages and avidin-fluorescein conjugates revealed many aggregates. Even at low phage concentrations, avidin induced inhibition of infection significantly. Anti-M13 phage antibody also made aggregates and inhibited the infection but in a different manner from avidin. The inhibition by avidin was at > or = 2 microg/ml, time dependent and marked until 10 min after the mixing of the BIO-phages and Escherichia coli. On the other hand, antibody inhibited the infection at > or = 0.1 microg/ml dose dependently, and the inhibition was time dependent and marked until 45 min after the mixing at moderate and low phage concentrations. These results indicate that avidin against BIO-phages and antibodies are agglutogens, and the inhibition of the BIO-phages by avidin is closely related to the tetramerization of avidin. Agglutogens may be novel alternative antiviral drugs.  (日)    [継承]
キーワード (推奨): 1. (英) Avidin (日) (読) [継承]
2. (英) Bacteriophage M13 (日) (読) [継承]
3. (英) Biotin (日) (読) [継承]
4. (英) Dose-Response Relationship, Drug (日) (読) [継承]
5.大腸菌 (Escherichia coli) [継承]
6. (英) Time Factors (日) (読) [継承]
7. (英) Viruses (日) (読) [継承]
発行所 (推奨):
誌名 (必須): FEBS Letters ([Federation of European Biochemical Societies])
(pISSN: 0014-5793, eISSN: 1873-3468)

ISSN (任意): 0014-5793
ISSN: 0014-5793 (pISSN: 0014-5793, eISSN: 1873-3468)
Title: FEBS letters
Title(ISO): FEBS Lett
Supplier: Federation of European Biochemical Societies
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2002年 6月 5日 (平成 14年 6月 5日) [継承]
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DOI (任意): 10.1016/S0014-5793(02)02772-2    (→Scopusで検索) [継承]
PMID (任意): 12044874    (→Scopusで検索) [継承]
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WOS (任意): 000176153000015 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anatomy and Cell Biology, School of Medicine, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. michy@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Michihiro Nakamura, Kouhei Tsumoto, Kazunori Ishimura and Izumi Kumagai : The effect of an agglutogen on virus infection: biotinylated filamentous phages and avidin as a model., FEBS Letters, Vol.520, No.1-3, 77-80, 2002.
欧文冊子 ● Michihiro Nakamura, Kouhei Tsumoto, Kazunori Ishimura and Izumi Kumagai : The effect of an agglutogen on virus infection: biotinylated filamentous phages and avidin as a model., FEBS Letters, Vol.520, No.1-3, 77-80, 2002.

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