『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=98365EID:98365, Map:0, LastModified:2012年9月11日(火) 14:20:03, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[永廣 信治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1.西 京子 ([徳島大学.病院.中央診療施設等.卒後臨床研修センター])
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2.宇野 昌明
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3.福澤 健治
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4.堀口 英久
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5. (英) Shinno Kiyohito (日) (読)
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6.永廣 信治
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題名 (必須): (英) Clinicopathological significance of lipid peroxidation in carotid plaques.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Several reports have suggested an association between lipid peroxidation and human carotid atherosclerosis, but few reports have demonstrated a link between lipid peroxidation and carotid plaques in humans. In this study, we investigated the relationship between clinical features, histopathological characteristics and lipid peroxidation in patients undergoing carotid endarterectomy (CEA). Forty-one carotid plaques were obtained. A portion of the most severe lesions was subjected to histopathologic examination, and the remainder of the plaques examined for lipid peroxidation. Thiobarbituric acid-reactive substances (TBARS) values were determined as a marker for lipid peroxidation. The lipid-rich core (LC) and macrophage infiltration (Mphi) component as a percentage of total plaque area were measured morphometrically. Based on the results, all plaques were classified into four groups. Group I (GI): LC <10%; Group IIa (GIIa): LC 10-30%, Mphi <5%; Group IIb (GIIb): LC 10-30%, Mphi < or = 5%, and Group III (GIII): LC < or =30%. The plaque TBARS values of GIII were significantly higher than those of GI, GIIa, and GIIb. The TBARS values of GIIb were one-and-a-half times higher than those of GIIa. Our results show that lipid peroxidation in carotid plaques is significantly associated with carotid atherosclerosis, especially plaque instability. These findings provide direct evidence of an association between lipid peroxidation and human atherosclerosis.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Aged, 80 and over (日) (読) [継承]
3. (英) Carotid Arteries (日) (読) [継承]
4. (英) Carotid Artery Diseases (日) (読) [継承]
5. (英) Endarterectomy, Carotid (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9.脂質過酸化 (lipid peroxidation) [継承]
10. (英) Lipids (日) (読) [継承]
11. (英) Macrophages (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Middle Aged (日) (読) [継承]
14. (英) Thiobarbituric Acid Reactive Substances (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Atherosclerosis (European Atherosclerosis Society)
(pISSN: 0021-9150, eISSN: 1879-1484)

ISSN (任意): 0021-9150
ISSN: 0021-9150 (pISSN: 0021-9150, eISSN: 1879-1484)
Title: Atherosclerosis
Title(ISO): Atherosclerosis
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2002年 2月 初日 (平成 14年 2月 初日) [継承]
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DOI (任意): 10.1016/S0021-9150(01)00583-4    (→Scopusで検索) [継承]
PMID (任意): 11849650    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Neurological Surgery, School of Medicine, The University of Tokushima, 3-18-15, Tokushima Kuramoto-cho 770-8503, Japan. neuros@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kyoko Nishi, Masaaki Uno, Kenji Fukuzawa, Hidehisa Horiguchi, Kiyohito Shinno and Shinji Nagahiro : Clinicopathological significance of lipid peroxidation in carotid plaques., Atherosclerosis, Vol.160, No.2, 289-296, 2002.
欧文冊子 ● Kyoko Nishi, Masaaki Uno, Kenji Fukuzawa, Hidehisa Horiguchi, Kiyohito Shinno and Shinji Nagahiro : Clinicopathological significance of lipid peroxidation in carotid plaques., Atherosclerosis, Vol.160, No.2, 289-296, 2002.

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