『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Nagata Yoshifumi (日) (読)
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[継承]
2. (英) Inoue Hiroko (日) (読)
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3. (英) Yamada Koichi (日) (読)
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4. (英) Higashiyama Hiroyuki (日) (読)
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5. (英) Mishima Kenji (日) (読)
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6. (英) Kizu Yasuhiro (日) (読)
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7. (英) Takeda Ienaka (日) (読)
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8. (英) Mizuno Fumio (日) (読)
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9.林 良夫
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10. (英) Saito Ichiro (日) (読)
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題名 (必須): (英) Activation of Epstein-Barr virus by saliva from Sjogren's syndrome patients  (日)    [継承]
副題 (任意):
要約 (任意): (英) The aim of this study was to examine the mechanism of Epstein-Barr virus (EBV) activation by soluble factors from the inflamed salivary glands of patients with Sjogren's syndrome (SS). Saliva from SS patients was used to examine the regulation of EBV activation by an inflammatory salivary microenvironment. Transient transfection of the EBV-negative salivary gland cell line (HSY) with BZLF1, a trans-activating EBV gene promoter-fusion construct (Zp-luc), was used in this study. The results showed that under conditions where the BZLF1 promoter is activated by potent stimuli, SS saliva (from eight of 12 patients) exerts a significant effect on expression of the luciferase gene. A specific inhibitor of protein kinase C did not affect the SS saliva-induced Zp-luc activity, whereas treatment with inhibitors of calmodulin, calcineurin and IP3, dose-dependently decreased this induction. Transforming growth factor beta1 (TGF-beta1), which is known to be expressed in SS salivary glands, dose-dependently induced Zp-luc activity. Hence, these results demonstrate the activation of EBV by SS saliva and suggest that EBV activation at the inflammatory site may occur in the presence of TGF-beta1 via triggering of the mitogen-activated protein kinase (MAPK) kinase signalling pathway.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Biological Factors (日) (読) [継承]
3. (英) Calcium-Calmodulin-Dependent Protein Kinases (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) DNA-Binding Proteins (日) (読) [継承]
6. (英) Enzyme Inhibitors (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Herpesvirus 4, Human (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) MAP Kinase Signaling System (日) (読) [継承]
11. (英) Promoter Regions, Genetic (日) (読) [継承]
12. (英) Protein Kinase C (日) (読) [継承]
13. (英) Saliva (日) (読) [継承]
14. (英) Salivary Glands (日) (読) [継承]
15. (英) Signal Transduction (日) (読) [継承]
16. (英) Sjogren's Syndrome (日) (読) [継承]
17. (英) Trans-Activators (日) (読) [継承]
18. (英) Transfection (日) (読) [継承]
19. (英) Transforming Growth Factor beta (日) (読) [継承]
20. (英) Transforming Growth Factor beta1 (日) (読) [継承]
21. (英) Viral Proteins (日) (読) [継承]
22. (英) Virus Activation (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)

ISSN (任意): 0019-2805
ISSN: 0019-2805 (pISSN: 0019-2805, eISSN: 1365-2567)
Title: Immunology
Title(ISO): Immunology
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2003年 0月 初日 (平成 15年 0月 初日) [継承]
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DOI (任意): 10.1111/j.0019-2805.2003.01795.x    (→Scopusで検索) [継承]
PMID (任意): 15027908    (→Scopusで検索) [継承]
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WOS (任意): 000188353900012 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1782400  (日)    [継承]

標準的な表示

和文冊子 ● Yoshifumi Nagata, Hiroko Inoue, Koichi Yamada, Hiroyuki Higashiyama, Kenji Mishima, Yasuhiro Kizu, Ienaka Takeda, Fumio Mizuno, Yoshio Hayashi and Ichiro Saito : Activation of Epstein-Barr virus by saliva from Sjogren's syndrome patients, Immunology, Vol.111, No.2, 223-229, 2003.
欧文冊子 ● Yoshifumi Nagata, Hiroko Inoue, Koichi Yamada, Hiroyuki Higashiyama, Kenji Mishima, Yasuhiro Kizu, Ienaka Takeda, Fumio Mizuno, Yoshio Hayashi and Ichiro Saito : Activation of Epstein-Barr virus by saliva from Sjogren's syndrome patients, Immunology, Vol.111, No.2, 223-229, 2003.

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