| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 吉栖 正典
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| 2. | 北川 哲也
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| 3. | 増田 裕
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| 4. | 堀 隆樹
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| 5. | 北市 隆
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| 6. | (英) Ogawa Yoshihiro (日) 小川 佳宏 (読) おがわ よしひろ
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| 7. | (英) Katoh Itsuo (日) 加藤 逸夫 (読) かとう いつお
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| 8. | 芳地 一
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| ○題名 (必須): | □ | (英) Changes in plasma free and sulfoconjugated dopamine in patients with congenital heart disease who underwent cardiac opreation, (日)
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| ○要約 (任意): | □ | (英) It has been suggested that plasma sulfoconjugated dopamine (DA) may serve as a source or reservoir for free DA in plasma. Moreover, it has also been reported that the plasma levels of conjugated DA may be used as an index predicting heart failure in patients with heart disease. Therefore, in the present study, we have measured the plasma levels of free and sulfoconjugated DA in patients with congenital heart disease who underwent total corrective operations. The patients were divided into two groups with (6 patients with tetralogy of Fallot, TOF) or without (5 patients with ventricular septal defect without pulmonary hypertension, VSD) cyanosis (mean age of 2.11 years). Blood samples were collected before and after operation from the patients, and plasma free and sulfoconjugated DA levels were measured using high performance liquid chromatography. Preoperative levels of free DA in patients in both groups were higher than the level in age matched control subjects. The plasma level of conjugated DA in TOF was higher than that in the controls and was the highest in VSD before operation. DA infusion early after operation caused a rise in plasma free and conjugated DA, however, the levels of increased free DA were lower in the VSD than in the TOF group. After discontinuing DA infusion, the plasma levels of free DA remained higher, while those of conjugated DA decreased to a level lower than the preoperative values in both groups. As the plasma levels of free and sulfoconjugated DA vary with hemodynamics, it was assumed that the difference in the plasma sulfoconjugated DA level between the groups before operation was due to the influence of pulminary blood flow on catecholamine homeostasis. Since the decrease in conjugated DA has been postulated to be an index of sustained heart failure, it is conceivable that it takes a long time for patients who underwent cardiac operations in infancy to recover from heart failure. (日)
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| ○キーワード (推奨): | 1. | (英) congenital heart disease (日) (読)
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| 2. | ドーパミン (dopamine)
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| 3. | (英) sulfoconjugation (日) (読)
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| 4. | (英) deconjugation (日) (読)
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| 5. | (英) cardiac surgery (日) (読)
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| ○発行所 (推奨): | □ | 特定非営利活動法人 日本胸部外科学会
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| ○誌名 (必須): | □ | 日本胸部外科学会雑誌 ([特定非営利活動法人 日本胸部外科学会])
(pISSN: 1344-4964, eISSN: 1863-2092)
| ○ISSN (任意): | □ | 1344-4964
ISSN: 1344-4964
(pISSN: 1344-4964, eISSN: 1863-2092) Title: The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshiTitle(ISO): Jpn J Thorac Cardiovasc SurgPublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(Scopus)
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| ○巻 (必須): | □ | 46
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 651 656
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| ○年月日 (必須): | □ | 西暦 1998年 8月 10日 (平成 10年 8月 10日)
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| ○URL (任意): | □ | http://ci.nii.ac.jp/naid/10007710289/
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| ○DOI (任意): |
| ○PMID (任意): | □ | 9785858 (→Scopusで検索)
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| ○CRID (任意): | □ | 1573668924328230528
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| ○NAID : | □ | 10007710289
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Pharmacology, University of Tokushima School of Medicine, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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