『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.情報統合医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.山本 登志子
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Yokoi Hiromichi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Tsuruo Yoshihiro (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Watanabe Kikuko (日) (読)
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学籍番号 (推奨):
[継承]
5.石村 和敬
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Identification of prostaglandin F-producing cells in the liver.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Prostaglandin (PG) F synthase forms PGF(2alpha) and 9alpha, 11beta-PGF2 from PGH2 and PGD2, respectively. PGH2 is synthesized from arachidonic acid by cyclooxygenase (COX) and then metabolized to various PGs and thromboxane by specific enzymes. PGD2 is synthesized from PGH2 by PGD synthase. To identify PGF2-producing cells in the rat liver, the occurrence and localization of PGF synthase and COX were studied with immunochemical and immunohistochemical techniques using anti-liver-type PGF synthase and anti-COX antibodies. In Western blot analyses, positive bands of liver-type PGF synthase and constitutive COX-1 were observed at positions approximately 37 kDa and 70-72 kDa, respectively. However, inducible COX-2 was not detected. In the immunohistochemical study, PGF synthase was present in the cytoplasm of the sinusoidal endothelial cells. COX-1 was present on the membranes of the nucleus and endoplasmic reticulum of the endothelial cells and Kupffer cells. Double immunostaining for PGF synthase and COX-1 showed that both enzymes were present in the same endothelial cells. These results suggest that the main site of PGF2 synthesis in the liver is the sinusoidal endothelial cell.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibody Specificity (日) (読) [継承]
3. (英) Cattle (日) (読) [継承]
4. (英) Cyclooxygenase 1 (日) (読) [継承]
5. (英) Dinoprost (日) (読) [継承]
6. (英) Endothelium (日) (読) [継承]
7. (英) Hydroxyprostaglandin Dehydrogenases (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9. (英) Isoenzymes (日) (読) [継承]
10. (英) Kupffer Cells (日) (読) [継承]
11. (英) Liver (日) (読) [継承]
12. (英) Membrane Proteins (日) (読) [継承]
13. (英) Microscopy, Immunoelectron (日) (読) [継承]
14. (英) Prostaglandin-Endoperoxide Synthases (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Rats, Wistar (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Histochemistry and Cell Biology (Society for Histochemistry)
(pISSN: 0948-6143, eISSN: 1432-119X)

ISSN (任意): 0948-6143
ISSN: 0948-6143 (pISSN: 0948-6143, eISSN: 1432-119X)
Title: Histochemistry and cell biology
Title(ISO): Histochem Cell Biol
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 112 [継承]
(必須): 6 [継承]
(必須): 451 456 [継承]
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年月日 (必須): 西暦 1999年 12月 初日 (平成 11年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s004180050428    (→Scopusで検索) [継承]
PMID (任意): 10651096    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000084673800007 [継承]
Scopus (任意): 2-s2.0-0033496658 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Toshiko Suzuki-Yamamoto, Hiromichi Yokoi, Yoshihiro Tsuruo, Kikuko Watanabe and Kazunori Ishimura : Identification of prostaglandin F-producing cells in the liver., Histochemistry and Cell Biology, Vol.112, No.6, 451-456, 1999.
欧文冊子 ● Toshiko Suzuki-Yamamoto, Hiromichi Yokoi, Yoshihiro Tsuruo, Kikuko Watanabe and Kazunori Ishimura : Identification of prostaglandin F-producing cells in the liver., Histochemistry and Cell Biology, Vol.112, No.6, 451-456, 1999.

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