『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.情報統合医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1. (英) Mahmud Ishtiaq (日) (読)
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学籍番号 (推奨):
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2.鈴木 登志子 (->個人[山本 登志子])
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3. (英) Yamamoto Yasuchika (日) (読)
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4. (英) Suzuki Hioshi (日) (読)
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5. (英) Takahashi Yoshitaka (日) (読)
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6. (英) Yoshimoto Tanihiro (日) (読)
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7. (英) Yamamoto Shozo (日) (読)
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題名 (必須): (英) Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation  (日)    [継承]
副題 (任意):
要約 (任意): (英) When human erythroleukemia (HEL) cells were incubated with arachidonic acid, both fatty acid cyclooxygenase and arachidonate 12-lipoxygenase activities were exhibited. Subcellular localization of these enzymes were examined by differential centrifugation, and both the cyclooxygenase and the 12-lipoxygenase were present predominantly in the microsomes rather than the cytosol of the cells. The cyclooxygenase activity was stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) in a dose-dependent and time-dependent manner. Actual increase in the cyclooxygenase protein by TPA was demonstrated by immunoprecipitation and Western blot analysis of the enzyme with the aid of an anti-cyclooxygenase antibody. Furthermore, the cyclooxygenase mRNA level increased as assessed by RNA blot analysis using a cDNA probe for the enzyme. In contrast, the TPA treatment reduced the activity of 12-lipoxygenase. By RNA blot analysis using a cDNA probe of HEL cell 12-lipoxygenase, the mRNA level of the enzyme was shown to decline by the TPA treatment. Taken together, the TPA treatment of HEL cells brought about the induction of cyclooxygenase and the suppression of 12-lipoxygenase.  (日)    [継承]
キーワード (推奨): 1. (英) Cyclooxygenase (日) (読) [継承]
2. (英) 12-Lipoxygenase (日) (読) [継承]
3. (英) Differentiaton (日) (読) [継承]
4. (英) phorbol ester-induced (日) (読) [継承]
5. (英) (Human erythroleukemia cell) (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ([Elsevier Science])
(pISSN: 0005-2760)

ISSN (任意): 0005-2760
ISSN: 0005-2760 (pISSN: 0005-2760)
Title: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher: Elsevier BV
 (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 2-3 [継承]
(必須): 211 216 [継承]
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年月日 (必須): 西暦 1993年 2月 24日 (平成 5年 2月 24日) [継承]
URL (任意): http://dx.doi.org/10.1016/0005-2760(93)90099-U [継承]
DOI (任意): 10.1016/0005-2760(93)90099-U    (→Scopusで検索) [継承]
PMID (任意): 8443239    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, Tokushima University School of Medicine, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ishtiaq Mahmud, Toshiko Suzuki, Yasuchika Yamamoto, Hioshi Suzuki, Yoshitaka Takahashi, Tanihiro Yoshimoto and Shozo Yamamoto : Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1166, No.2-3, 211-216, 1993.
欧文冊子 ● Ishtiaq Mahmud, Toshiko Suzuki, Yasuchika Yamamoto, Hioshi Suzuki, Yoshitaka Takahashi, Tanihiro Yoshimoto and Shozo Yamamoto : Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1166, No.2-3, 211-216, 1993.

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