『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=96989EID:96989, Map:0, LastModified:2017年12月19日(火) 14:54:25, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.総合科学部.社会創生学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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著者 (必須): 1.山本 裕史
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2. (英) Liljestrand, M. Howard (日) (読)
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題名 (必須): (英) Partitioning of selected estrogenic compounds between synthetic membrane vesicles and water: effects of lipid components  (日)    [継承]
副題 (任意):
要約 (任意): (英) Partition coefficients of the steroid estrogens 17beta-estradiol, estriol, estrone, and 17alpha-ethynylestradiol and the industrial estrogenic compounds p-nonylphenol, p-(tert)octylphenol, bisphenol A, butylbenzylphthalate, and dibutylphthalate between liposome membrane vesicles and water (K(lipw) values) were determined using equilibrium dialysis. A moderate linear correlation with R2 values of as low as 0.679 were found for the relationship between log K(lipw) and log K(ow) for these compounds. Effects of lipid components used to prepare the membrane vesicles on the partitioning of 17beta-estradiol and p-nonylphenol were also evaluated. For both, K(lipw) values were larger for the vesicles prepared from phospholipids composed of shorter acyl chains such as dilauroyl-phosphatidylcholine than those composed of longer acyl chains such as distearoylphosphatidylcholine. Partition coefficients were higher for the vesicles prepared from phospholipids including unsaturated acyl chains such as dioleoyl-phosphatidylcholine than those solely composed of saturated acyl chains such as distearoyl-phosphatidylcholine. Both shorter acyl chains and double bonds resulted in a more fluid conformation of the lipid bilayer with the liquid crystalline phase rather than the gel phase and greater partitioning. In contrast, higher cholesterol contents reduced the partitioning coefficient. The presence of cholesterol in the void of the lipid bilayer possibly led to the stabilization of the bilayer and the decrease in the partitioning of 17beta-estradiol or p-nonylphenol molecules. These results suggest that phase transition is of critical importance in selecting lipid components to evaluate the bioconcentration for these compounds.  (日)    [継承]
キーワード (推奨): 1. (英) Biological Availability (日) (読) [継承]
2. (英) Cell Membrane (日) (読) [継承]
3. (英) Estrogens (日) (読) [継承]
4.リポソーム (liposomes) [継承]
5. (英) Membranes, Artificial (日) (読) [継承]
6. (英) Models, Theoretical (日) (読) [継承]
7. (英) Water (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Environmental Science and Technology ([アメリカ化学会])
(pISSN: 0013-936X, eISSN: 1520-5851)

ISSN (任意): 0013-936X
ISSN: 0013-936X (pISSN: 0013-936X, eISSN: 1520-5851)
Title: Environmental science & technology
Title(ISO): Environ Sci Technol
Publisher: American Chemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 38 [継承]
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(必須): 1139 1147 [継承]
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年月日 (必須): 西暦 2004年 2月 15日 (平成 16年 2月 15日) [継承]
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PMID (任意): 14998029    (→Scopusで検索) [継承]
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WOS (任意): 000188996600030 [継承]
Scopus (任意): 2-s2.0-1242342800 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Civil Engineering, The University of Texas at Austin, 1 University Station C1786, Austin, Texas 78712-0273, USA. yamamoto.hiroshi@nies.go.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hiroshi Yamamoto and Howard M. Liljestrand : Partitioning of selected estrogenic compounds between synthetic membrane vesicles and water: effects of lipid components, Environmental Science and Technology, Vol.38, No.4, 1139-1147, 2004.
欧文冊子 ● Hiroshi Yamamoto and Howard M. Liljestrand : Partitioning of selected estrogenic compounds between synthetic membrane vesicles and water: effects of lipid components, Environmental Science and Technology, Vol.38, No.4, 1139-1147, 2004.

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