『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.発生発達医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.澤田 和彦
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2. (英) Komatsu Suguru (日) 小松 克 (読) こまつ すぐる
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3.坂田 ひろみ
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4. (英) Sun Xue-Zhi (日) 孫 学智 (読) すん しゅえち
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5. (英) Hisano Setsuji (日) 久野 節二 (読) ひさの せつじ
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6.福井 義浩
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題名 (必須): (英) Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Expression of tyrosine hydroxylase (TH) was examined immunohistochemically in the cerebellum of two ataxic mutants, Rolling mouse Nagoya (RMN) and dilute-lethal mice (DL). In littermate controls of both mutants, a few TH-positive Purkinje cells were distributed sparsely and their number was smaller than in the mutants at any ages examined. In RMN, TH-positive Purkinje cells were distributed in lobule IX and X, and were arranged into parasagittal bands at 2 weeks of age. TH-positive Purkinje cells increased in number and were widely distributed throughout the vermis at 3 weeks of age. In adult RMN, TH-positive Purkinje cells were found in all lobules of the cerebellum. Their parasagittal bands also became evident in the hemisphere. In DL, TH-positive Purkinje cells were mainly distributed in vermal lobules IX and X, and the flocculus at 3 weeks of age. They were also found as bands in lobules IX and X. The results suggest that abnormal expression of TH in Purkinje cells may not be specific to the allelic group. Since TH promoter is activated by Ca2+, TH expression in the mutant Purkinje cells may predict neuronal dysfunction caused by alterations in cellular Ca2+ currents.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Calcium Channels (日) (読) [継承]
3. (英) Cerebellar Ataxia (日) (読) [継承]
4.免疫組織化学 (immunohistochemistry) [継承]
5. (英) Mice (日) (読) [継承]
6. (英) Mice, Neurologic Mutants (日) (読) [継承]
7. (英) Neurons (日) (読) [継承]
8. (英) Tyrosine 3-Monooxygenase (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Brain Research ([Elsevier Science])
(pISSN: 0006-8993, eISSN: 1872-6240)

ISSN (任意): 0006-8993
ISSN: 0006-8993 (pISSN: 0006-8993, eISSN: 1872-6240)
Title: Brain research
Title(ISO): Brain Res
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 107 112 [継承]
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年月日 (必須): 西暦 1999年 5月 22日 (平成 11年 5月 22日) [継承]
URL (任意):
DOI (任意): 10.1016/S0006-8993(99)01347-5    (→Scopusで検索) [継承]
PMID (任意): 10350535    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0033594796 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuhiko Sawada, Suguru Komatsu, Hiromi Sakata-Haga, Xue-Zhi Sun, Setsuji Hisano and Yoshihiro Fukui : Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice, Brain Research, Vol.829, No.1-2, 107-112, 1999.
欧文冊子 ● Kazuhiko Sawada, Suguru Komatsu, Hiromi Sakata-Haga, Xue-Zhi Sun, Setsuji Hisano and Yoshihiro Fukui : Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice, Brain Research, Vol.829, No.1-2, 107-112, 1999.

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