『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=95897)

EID=95897EID:95897, Map:0, LastModified:2018年2月9日(金) 11:03:38, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.発生発達医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.澤田 和彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.坂田 ひろみ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Hisano Setsuji (日) 久野 節二 (読) ひさの せつじ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.福井 義浩
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Topological relationship between corticotropin-releasing factor-immunoreactive cerebellar afferents and tyrosine hydroxylase-immunoreactive Purkinje cells in a hereditary ataxic mutant, rolling mouse Nagoya  (日)    [継承]
副題 (任意):
要約 (任意): (英) Using immunohistochemistry we examined the distribution of corticotropin-releasing factor-positive cerebellar afferents and the topological relationship between their projections and the distribution of tyrosine hydroxylase-positive Purkinje cells in an ataxic mutant, rolling mouse Nagoya. In the mutants, some climbing fibers were more intensely stained for corticotropin-releasing factor, but their zonal distribution remained the same as in non-ataxic littermates (control mice). These climbing fibers arose from the dorsal accessory nucleus, the ventral lamella of principal nucleus, the dorsomedial cell group, the subnucleus A, the beta subnucleus and the ventrolateral protrusion of the inferior olive, since perikarya in these olivary subdivisions were more intensely stained for corticotropin-releasing factor than in controls. Some mossy fiber rosettes in the vermal lobules, the simple lobule, the crus I of ansiform lobule, the copula pyramidis and the flocculus also exhibited corticotropin-releasing factor immunoreactivity and were more densely stained in the mutants than in controls. Double immunostaining for corticotropin-releasing factor and tyrosine hydroxylase in the mutant cerebellum revealed that the distribution of tyrosine hydroxylase-positive Purkinje cells corresponded to terminal fields of corticotropin-releasing factor-positive climbing fibers but not corticotropin-releasing factor-positive mossy fibers. This study indicated an increased corticotropin-releasing factor immunoreactivity in some climbing or mossy fibers in the cerebellum of rolling mouse Nagoya. We also found that the distribution of tyrosine hydroxylase-positive Purkinje cells corresponded to terminal fields of corticotropin-releasing factor-positive climbing fibers in the mutant cerebellum. As the transcription of the tyrosine hydroxylase gene is facilitated by Ca2+, abnormal tyrosine hydroxylase expression in the mutant Purkinje cells may indicate functional abnormality by alterations in intracellular Ca2+ concentrations. Therefore, we suggest that an increased level of corticotropin-releasing factor in a specific population of climbing fibers may alter the function of their target Purkinje cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies (日) (読) [継承]
3. (英) Cerebellar Ataxia (日) (読) [継承]
4. (英) Cerebellar Nuclei (日) (読) [継承]
5. (英) Corticotropin-Releasing Hormone (日) (読) [継承]
6.免疫組織化学 (immunohistochemistry) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Neurologic Mutants (日) (読) [継承]
10. (英) Nerve Fibers (日) (読) [継承]
11. (英) Neurons, Afferent (日) (読) [継承]
12. (英) Olivary Nucleus (日) (読) [継承]
13. (英) Purkinje Cells (日) (読) [継承]
14. (英) RNA, Messenger (日) (読) [継承]
15. (英) Tyrosine 3-Monooxygenase (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Neuroscience ([International Brain Research Organization])
(pISSN: 0306-4522, eISSN: 1873-7544)

ISSN (任意): 0306-4522
ISSN: 0306-4522 (pISSN: 0306-4522, eISSN: 1873-7544)
Title: Neuroscience
Title(ISO): Neuroscience
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 102 [継承]
(必須): 4 [継承]
(必須): 925 935 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 2月 初日 (平成 13年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/S0306-4522(00)00533-9    (→Scopusで検索) [継承]
PMID (任意): 11182254    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000167232300016 [継承]
Scopus (任意): 2-s2.0-0035857451 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuhiko Sawada, Hiromi Sakata-Haga, Setsuji Hisano and Yoshihiro Fukui : Topological relationship between corticotropin-releasing factor-immunoreactive cerebellar afferents and tyrosine hydroxylase-immunoreactive Purkinje cells in a hereditary ataxic mutant, rolling mouse Nagoya, Neuroscience, Vol.102, No.4, 925-935, 2001.
欧文冊子 ● Kazuhiko Sawada, Hiromi Sakata-Haga, Setsuji Hisano and Yoshihiro Fukui : Topological relationship between corticotropin-releasing factor-immunoreactive cerebellar afferents and tyrosine hydroxylase-immunoreactive Purkinje cells in a hereditary ataxic mutant, rolling mouse Nagoya, Neuroscience, Vol.102, No.4, 925-935, 2001.

関連情報

Number of session users = 5, LA = 12.36, Max(EID) = 383436, Max(EOID) = 1024855.