『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=95859EID:95859, Map:0, LastModified:2012年9月14日(金) 16:41:04, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.プロテオミクス医科学部門.生体制御医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1. (英) Ewis AA (日) (読)
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2. (英) Lee J (日) (読)
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3.新家 利一
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4.中堀 豊
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題名 (必須): (英) Microdeletions of a Y-specific marker, Yfm1, and implications for a role in spermatogenesis  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have detected deletions of a Y-specific microsatellite marker, Yfm1, located on the Y chromosome (Yq) within interval 6 and near the DAZ (deleted in azoospermia) genes, in 9/89 oligospermic and 17/68 azoospermic Japanese men. No Yfm1 deletions were detected in the 150 normal fertile males examined as controls. Yfm1 deletions in the oligo- and azoospermic males were associated with other deletions that removed entire DAZ genes in those infertile men. These deletions indicated that all Yfm1 loci are located within azoospermia factor c (AZFc) in interval 6 on the long arm of the Y chromosome. Mapping Yfm1 on the Y chromosome using the draft sequence of the human genome revealed that at least three Yfm1 loci are located within about 25-30 kbp of the DAZ genes. Moreover, the Yfm1 marker showed the least number of copies in Japanese males derived from a Y chromosomal lineage called haplotype II, defined by having the Y Alu polymorphism (YAP) insertion. Males from this haplotype II lineage are known from our previous studies to have lower spermatogenic abilities, with higher rates of oligo- and azoospermia than other haplotypes. The least number of Yfm1 loci, whose copy number may correspond to that of the DAZ genes, may be a risk factor predisposing an individual to azoospermia or oligospermia.  (日)    [継承]
キーワード (推奨): 1. (英) Alu Elements (日) (読) [継承]
2. (英) Gene Deletion (日) (読) [継承]
3. (英) Gene Dosage (日) (読) [継承]
4. (英) Genetic Loci (日) (読) [継承]
5. (英) Genome, Human (日) (読) [継承]
6. (英) Genotype (日) (読) [継承]
7. (英) Haplotypes (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Microsatellite Repeats (日) (読) [継承]
11. (英) Oligospermia (日) (読) [継承]
12. (英) RNA-Binding Proteins (日) (読) [継承]
13. (英) Seminal Plasma Proteins (日) (読) [継承]
14. (英) Spermatogenesis (日) (読) [継承]
15.Y染色体 (Y chromosome) [継承]
発行所 (推奨):
誌名 (必須): Journal of Human Genetics (日本人類遺伝学会)
(pISSN: 1434-5161, eISSN: 1435-232X)

ISSN (任意): 1434-5161
ISSN: 1434-5161 (pISSN: 1434-5161, eISSN: 1435-232X)
Title: Journal of human genetics
Title(ISO): J Hum Genet
Publisher: Springer Science+Business Media
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 47 [継承]
(必須): 5 [継承]
(必須): 257 261 [継承]
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年月日 (必須): 西暦 2002年 5月 初日 (平成 14年 5月 初日) [継承]
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DOI (任意): 10.1007/s100380200035    (→Scopusで検索) [継承]
PMID (任意): 12032594    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Public Health, School of Medicine, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● AA Ewis, J Lee, Toshikatsu Shinka and Yutaka Nakahori : Microdeletions of a Y-specific marker, Yfm1, and implications for a role in spermatogenesis, Journal of Human Genetics, Vol.47, No.5, 257-261, 2002.
欧文冊子 ● AA Ewis, J Lee, Toshikatsu Shinka and Yutaka Nakahori : Microdeletions of a Y-specific marker, Yfm1, and implications for a role in spermatogenesis, Journal of Human Genetics, Vol.47, No.5, 257-261, 2002.

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