『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=95828EID:95828, Map:0, LastModified:2013年1月10日(木) 14:44:30, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.医学部.医学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.プロテオミクス医科学部門.生体制御医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.新家 利一
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2. (英) Sato Yoko (日) (読)
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3. (英) Chen Gang (日) (読)
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4.奈路田 拓史
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5. (英) Kinoshita Keigo (日) (読)
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[継承]
6. (英) Unemi Yukiko (日) (読)
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7. (英) Tsuji Keiko (日) (読)
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8.樋田 一徳
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9. (英) Iwamoto Teruaki (日) (読)
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10.中堀 豊
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題名 (必須): (英) Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility  (日)    [継承]
副題 (任意):
要約 (任意): (英) Azoospermia and oligospermia are major causes of male infertility. Some genes located on the Y chromosome are suggested as candidates. Recently, HSFY, which is similar to the HSF (heat shock transcription factor) family, has been mapped on the human Y chromosome as multicopies. However, newly available sequence data deposited at NCBI shows that only the HSFY gene located on Yq has a long open reading frame containing a HSF-type DNA-binding domain. HSFY is similar to LW-1 on the human X chromosome and a murine HSFY-like sequence (mHSFYL), 4933413G11Rik, on the mouse chromosome 1. LW-1 and mHSFYL have 53% and 70% homology to HSFY for amino acid sequences of their presumed DNA-binding domains, respectively. Comparison of the presumed DNA-binding domains unveiled that the three HSF-like factors, HSFY, LW-1, and mHSFYL, belong to a different class than conventional HSFs. When we screened for deletions on the Yq of males suffering from infertility, we found that HSFY was involved in interstitial deletions on the Y chromosomes for two azoospermic males who had DBY, USP9Y, and DAZ but did not have RBMY located on the AZFb. Expression analysis of HSFY, LW-1, and mHSFYL unveiled that they are expressed predominantly in testis. Furthermore, immunhistochemistry of HSFY in testis showed that its expression is restricted to both Sertoli cells and spermatogenic cells and that it exhibits a stage-dependent translocation from the cytoplasm to the nucleus in spermatogenetic cells during spermatogenesis. These results may suggest that deletion of HSFY is involved in azoospermia or oligospermia.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Amino Acid Sequence (日) (読) [継承]
3. (英) Blotting, Western (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Chromosomes, Human, Y (日) (読) [継承]
6. (英) DNA Mutational Analysis (日) (読) [継承]
7. (英) DNA-Binding Proteins (日) (読) [継承]
8. (英) Gene Deletion (日) (読) [継承]
9. (英) Heat-Shock Proteins (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11.免疫組織化学 (immunohistochemistry) [継承]
12. (英) Infertility, Male (日) (読) [継承]
13. (英) Intracellular Fluid (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Middle Aged (日) (読) [継承]
16. (英) Molecular Sequence Data (日) (読) [継承]
17. (英) Oligospermia (日) (読) [継承]
18. (英) Phylogeny (日) (読) [継承]
19. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
20. (英) Sequence Homology, Amino Acid (日) (読) [継承]
21. (英) Testis (日) (読) [継承]
22. (英) Tissue Distribution (日) (読) [継承]
23. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨): (英) Society for the Study of Reproduction (日) (読) [継承]
誌名 (必須): Biology of Reproduction (The Society for the Study of Reproduction)
(pISSN: 0006-3363, eISSN: 1529-7268)

ISSN (任意): 0006-3363
ISSN: 0006-3363 (pISSN: 0006-3363, eISSN: 1529-7268)
Title: Biology of reproduction
Title(ISO): Biol Reprod
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2004年 7月 初日 (平成 16年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.1095/biolreprod.103.023580    (→Scopusで検索) [継承]
PMID (任意): 15044259    (→Scopusで検索) [継承]
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WOS (任意): 000222220700038 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Human Genetics and Public Health, Graduate School of Proteomics, Faculty of Medicine, The University of Tokushima, Tokushima-City, 770-8503 Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Toshikatsu Shinka, Yoko Sato, Gang Chen, Takushi Naroda, Keigo Kinoshita, Yukiko Unemi, Keiko Tsuji, Kazunori Toida, Teruaki Iwamoto and Yutaka Nakahori : Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility, Biology of Reproduction, Vol.71, No.1, 297-306, 2004.
欧文冊子 ● Toshikatsu Shinka, Yoko Sato, Gang Chen, Takushi Naroda, Keigo Kinoshita, Yukiko Unemi, Keiko Tsuji, Kazunori Toida, Teruaki Iwamoto and Yutaka Nakahori : Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility, Biology of Reproduction, Vol.71, No.1, 297-306, 2004.

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