『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
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共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.歯学部.歯学科 [継承]
著者 (必須): 1. (英) Kurabuchi Shingo (日) (読) くらぶち しんご
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学籍番号 (推奨):
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2.細井 和雄
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3. (英) Gresik W Edward (日) (読)
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題名 (必須): (英) Androgen regulation of the cellular distribution of the true tissue kallikrein mK1 in the submandibular gland of the mouse  (日)    [継承]
副題 (任意):
要約 (任意): (英) The kallikrein gene family encodes for at least four different proteases in the mouse submandibular gland (SMG): mK1 (true tissue kallikrein), mK9, mK13, and mK22. These enzymes and many other biologically active proteins are synthesized by the granular convoluted tubule (GCT), a specialized segment of the SMG duct system. The GCT is under multihormonal regulation by androgens, thyroid hormones, and adrenocortical hormones. Androgens suppress synthesis of mK1 in the SMG but enhance expression of the other three kallikreins. We prepared an antibody with limited immunoreactivity for mK1 and used it to examine the effects of androgen status on the distribution of this isozyme in the SMGs of developing and mature mice by immunoperoxidase staining for the light microscope and immunogold labeling for the electron microscope. In prepubertal mice, every immature GCT cell contains mK1, confined to an accumulation of small granules in the subluminal cytoplasm. In mature mice, not every GCT cell contains mK1, and in those cells that do there is considerable intergranular variation in the intensity of staining for mK1. GCT cells containing mK1 are much more abundant in the glands of females than of males, resulting in a peculiar sexually dimorphic mosaic distribution of this isozyme in the mature SMG. Castration of adult males increases the number of GCT cells expressing mK1. Administration of androgen to intact or castrated males or to intact females reduces the number of cells staining for mK1. In all cases, immunogold labeling for mK1 is confined to secretory granules. No fine structural differences were noted between cells that were positively or negatively stained for mK1. Therefore, although GCT cells appear to be composed of a uniform population of cells on the basis of morphology alone, they are not homogeneous in their content of secretory proteins. These results indicate that androgen regulation of GCT cells is more complex than has been appreciated to date.  (日)    [継承]
キーワード (推奨): 1. (英) Androgens (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antibody Specificity (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Immunoenzyme Techniques (日) (読) [継承]
6. (英) Isoenzymes (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Phenotype (日) (読) [継承]
10. (英) Sex Characteristics (日) (読) [継承]
11. (英) Sexual Maturation (日) (読) [継承]
12. (英) Submandibular Gland (日) (読) [継承]
13. (英) Tissue Distribution (日) (読) [継承]
14. (英) Tissue Kallikreins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Histochemistry and Cytochemistry (The Histochemical Society)
(pISSN: 0022-1554, eISSN: 1551-5044)

ISSN (任意): 0022-1554
ISSN: 0022-1554 (pISSN: 0022-1554, eISSN: 1551-5044)
Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Title(ISO): J Histochem Cytochem
Publisher: Histochemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 49 [継承]
(必須): 6 [継承]
(必須): 801 802 [継承]
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年月日 (必須): 西暦 2001年 6月 初日 (平成 13年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1177/002215540104900618    (→Scopusで検索) [継承]
PMID (任意): 11373331    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000169233300018 [継承]
Scopus (任意): 2-s2.0-0034971585 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Shingo Kurabuchi, Kazuo Hosoi and Edward W Gresik : Androgen regulation of the cellular distribution of the true tissue kallikrein mK1 in the submandibular gland of the mouse, The Journal of Histochemistry and Cytochemistry, Vol.49, No.6, 801-802, 2001.
欧文冊子 ● Shingo Kurabuchi, Kazuo Hosoi and Edward W Gresik : Androgen regulation of the cellular distribution of the true tissue kallikrein mK1 in the submandibular gland of the mouse, The Journal of Histochemistry and Cytochemistry, Vol.49, No.6, 801-802, 2001.

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