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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.The Cleveland Clinic Foundation [継承]
著者 (必須): 1. (英) Zhuang Shaowei (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Zhang Youhua (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Mowrey A. Kent (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Li Jianbo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5.田畑 智継
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学籍番号 (推奨):
[継承]
6. (英) Wallick W. Don (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Popovi B. Zoran (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Grimm A. Richard (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Natale Andrea (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Mazgalev N. Todor (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Ventricular rate control by selective vagal nerve stimulation is superior to rhythm regulation by atrioventricular nodal ablation and pacing during atrial fibrillation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Selective atrioventricular nodal (AVN) vagal stimulation (AVN-VS) has emerged as a novel strategy for ventricular rate (VR) control in atrial fibrillation (AF). Although AVN-VS preserves the physiological ventricular activation sequence, the resulting rate is slow but irregular. In contrast, AVN ablation with pacemaker implantation produces retrograde activation (starting at the apex), with regular ventricular rhythm. We tested the hypothesis that, at comparable levels of VR slowing, AVN-VS provides hemodynamic benefits similar to those of ablation with pacemaker implantation. AVN-VS was delivered to the epicardial fat pad that projects parasympathetic nerve fibers to the AVN in 12 dogs during AF. A computer-controlled algorithm adjusted AVN-VS beat by beat to achieve a mean ventricular RR interval of 75%, 100%, 125%, or 150% of spontaneous sinus cycle length. The AVN was then ablated, and the right ventricular (RV) apex was paced either irregularly (i-RVP) using the RR intervals collected during AVN-VS or regularly (r-RVP) at the corresponding mean RR. The results indicated that all 3 strategies improved hemodynamics compared with AF. However, AVN-VS resulted in significantly better responses than either r-RVP or i-RVP. i-RVP resulted in worse hemodynamic responses than r-RVP. The differences among these modes became less significant when mean VR was slowed to 150% of sinus cycle length. AVN-VS can produce graded slowing of the VR during AF without destroying the AVN. It was hemodynamically superior to AVN ablation with either r-RVP or i-RVP, indicating that the benefits of preserving the physiological antegrade ventricular activation sequence outweigh the detrimental effect of irregularity.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Atrial Fibrillation (日) (読) [継承]
3. (英) Atrioventricular Node (日) (読) [継承]
4. (英) Cardiac Pacing, Artificial (日) (読) [継承]
5. (英) Catheter Ablation (日) (読) [継承]
6. (英) Disease Models, Animal (日) (読) [継承]
7. (英) Dogs (日) (読) [継承]
8. (英) Echocardiography (日) (読) [継承]
9. (英) Electric Stimulation (日) (読) [継承]
10. (英) Electrophysiologic Techniques, Cardiac (日) (読) [継承]
11. (英) Heart (日) (読) [継承]
12. (英) Heart Rate (日) (読) [継承]
13. (英) Heart Ventricles (日) (読) [継承]
14. (英) Hemodynamics (日) (読) [継承]
15. (英) Treatment Outcome (日) (読) [継承]
16. (英) Vagus Nerve (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Circulation ([American Heart Association])
(pISSN: 0009-7322, eISSN: 1524-4539)

ISSN (任意): 1524-4539
ISSN: 0009-7322 (pISSN: 0009-7322, eISSN: 1524-4539)
Title: Circulation
Title(ISO): Circulation
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 106 [継承]
(必須): 14 [継承]
(必須): 1853 1858 [継承]
都市 (任意):
年月日 (必須): 西暦 2002年 10月 1日 (平成 14年 10月 1日) [継承]
URL (任意): http://circ.ahajournals.org/cgi/content/abstract/106/14/1853 [継承]
DOI (任意): 10.1161/01.CIR.0000031802.58532.04    (→Scopusで検索) [継承]
PMID (任意): 12356641    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000178385700022 [継承]
Scopus (任意):
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備考 (任意): 1.(英) Article.Affiliation: Department of Cardiovascular, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Shaowei Zhuang, Youhua Zhang, Kent A. Mowrey, Jianbo Li, Tomotsugu Tabata, Don W. Wallick, Zoran B. Popovi, Richard A. Grimm, Andrea Natale and Todor N. Mazgalev : Ventricular rate control by selective vagal nerve stimulation is superior to rhythm regulation by atrioventricular nodal ablation and pacing during atrial fibrillation., Circulation, Vol.106, No.14, 1853-1858, 2002.
欧文冊子 ● Shaowei Zhuang, Youhua Zhang, Kent A. Mowrey, Jianbo Li, Tomotsugu Tabata, Don W. Wallick, Zoran B. Popovi, Richard A. Grimm, Andrea Natale and Todor N. Mazgalev : Ventricular rate control by selective vagal nerve stimulation is superior to rhythm regulation by atrioventricular nodal ablation and pacing during atrial fibrillation., Circulation, Vol.106, No.14, 1853-1858, 2002.

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