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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.Medical College of Wisconsin [継承]
著者 (必須): 1. (英) Gu Weidong (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Weihrauch Dorothee (日) (読)
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[継承]
3.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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学籍番号 (推奨):
[継承]
4. (英) Tessmer P. John (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Pagel S. Paul (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Kersten R. Judy (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Chilian M. William (日) (読)
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[継承]
8. (英) Warltier C. David (日) (読)
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[継承]
題名 (必須): (英) Reactive oxygen species are critical mediators of coronary collateral development in a canine model.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Recent evidence suggests that reactive oxygen species (ROS) promote proliferation and migration of vascular smooth muscle (VSMC) and endothelial cells (EC). We tested the hypothesis that ROS serve as crucial messengers during coronary collateral development. Dogs were subjected to brief (2 min), repetitive coronary artery occlusions (1/h, 8/day, 21 day duration) in the absence (occlusion, n = 8) or presence of N-acetylcysteine (NAC) (occlusion + NAC, n = 8). A sham group (n = 8) was instrumented identically but received no occlusions. In separate experiments, ROS generation after a single 2-min coronary artery occlusion was assessed with dihydroethidium fluorescence. Coronary collateral blood flow (expressed as a percentage of normal zone flow) was significantly increased (71 +/- 7%) in occlusion dogs after 21 days but remained unchanged (13 +/- 3%) in sham dogs. Treatment with NAC attenuated increases in collateral blood flow (28 +/- 8%). Brief coronary artery occlusion and reperfusion caused ROS production (256 +/- 33% of baseline values), which was abolished with NAC (104 +/- 12%). Myocardial interstitial fluid produced tube formation and proliferation of VSMC and EC in occlusion but not in NAC-treated or sham dogs. The results indicate that ROS are critical for the development of the coronary collateral circulation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Division (日) (読) [継承]
3. (英) Collateral Circulation (日) (読) [継承]
4. (英) Coronary Circulation (日) (読) [継承]
5. (英) Coronary Disease (日) (読) [継承]
6. (英) Coronary Vessels (日) (読) [継承]
7. (英) Dogs (日) (読) [継承]
8. (英) Endothelial Growth Factors (日) (読) [継承]
9. (英) Endothelium, Vascular (日) (読) [継承]
10. (英) Extracellular Space (日) (読) [継承]
11. (英) Intercellular Signaling Peptides and Proteins (日) (読) [継承]
12. (英) Lymphokines (日) (読) [継承]
13. (英) Muscle, Smooth, Vascular (日) (読) [継承]
14. (英) Myocardium (日) (読) [継承]
15. (英) Neovascularization, Pathologic (日) (読) [継承]
16. (英) Reactive Oxygen Species (日) (読) [継承]
17. (英) Vascular Endothelial Growth Factor A (日) (読) [継承]
18. (英) Vascular Endothelial Growth Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology, Heart and Circulatory Physiology ([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)

ISSN (任意): 0363-6135
ISSN: 0363-6135 (pISSN: 0363-6135, eISSN: 1522-1539)
Title: American journal of physiology. Heart and circulatory physiology
Title(ISO): Am J Physiol Heart Circ Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 285 [継承]
(必須): 4 [継承]
(必須): H1582 H1589 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 10月 初日 (平成 15年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1152/ajpheart.00318.2003    (→Scopusで検索) [継承]
PMID (任意): 12816750    (→Scopusで検索) [継承]
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WOS (任意): 000185249900027 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, Medical College of Wisconsin, 8701 Water-town Plank Road, Milwaukee, WI 53226, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Weidong Gu, Dorothee Weihrauch, Katsuya Tanaka, John P. Tessmer, Paul S. Pagel, Judy R. Kersten, William M. Chilian and David C. Warltier : Reactive oxygen species are critical mediators of coronary collateral development in a canine model., American Journal of Physiology, Heart and Circulatory Physiology, Vol.285, No.4, H1582-H1589, 2003.
欧文冊子 ● Weidong Gu, Dorothee Weihrauch, Katsuya Tanaka, John P. Tessmer, Paul S. Pagel, Judy R. Kersten, William M. Chilian and David C. Warltier : Reactive oxygen species are critical mediators of coronary collateral development in a canine model., American Journal of Physiology, Heart and Circulatory Physiology, Vol.285, No.4, H1582-H1589, 2003.

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