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EID=94649EID:94649, Map:0, LastModified:2013年6月21日(金) 16:30:43, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[田中 克哉], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.Medical College of Wisconsin [継承]
著者 (必須): 1.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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2. (英) Weihrauch D (日) (読)
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[継承]
3. (英) Ludwig LM (日) (読)
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[継承]
4. (英) Kersten JR (日) (読)
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[継承]
5. (英) Pagel PS (日) (読)
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[継承]
6. (英) Warltier DC (日) (読)
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[継承]
題名 (必須): (英) Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Whether the opening of mitochondrial adenosine triphosphate-regulated potassium (K(ATP)) channels is a trigger or an end effector of anesthetic-induced preconditioning is unknown. We tested the hypothesis that the opening of mitochondrial K(ATP) channels triggers isoflurane-induced preconditioning by generating reactive oxygen species (ROS) in vivo. Pentobarbital-anesthetized rabbits were subjected to a 30-min coronary artery occlusion followed by 3 h reperfusion. Rabbits were randomly assigned to receive a vehicle (0.9% saline) or the selective mitochondrial K(ATP) channel blocker 5-hydroxydecanoate (5-HD) alone 10 min before or immediately after a 30-min exposure to 1.0 minimum alveolar concentration (MAC) isoflurane. In another series of experiments, the fluorescent probe dihydroethidium was used to assess superoxide anion production during administration of 5-HD or the ROS scavengers N-acetylcysteine or N-2-mercaptopropionyl glycine (2-MPG) in the presence or absence of 1.0 MAC isoflurane. Myocardial infarct size and superoxide anion production were measured using triphenyltetrazolium staining and confocal fluorescence microscopy, respectively. Isoflurane (P < 0.05) decreased infarct size to 19 +/- 3% (mean +/- SEM) of the left ventricular area at risk as compared to the control (38 +/- 4%). 5-HD administered before but not after isoflurane abolished this beneficial effect (37 +/- 4% as compared to 24 +/- 3%). 5-HD alone had no effect on infarct size (42 +/- 3%). Isoflurane increased fluorescence intensity. Pretreatment with N-acetylcysteine, 2-MPG, or 5-HD before isoflurane abolished increases in fluorescence, but administration of 5-HD after isoflurane only partially attenuated increases in fluorescence produced by the volatile anesthetic agent. The results indicate that mitochondrial K(ATP) channel opening acts as a trigger for isoflurane-induced preconditioning by generating ROS in vivo.  (日)    [継承]
キーワード (推奨): 1. (英) Adenosine Triphosphatases (日) (読) [継承]
2. (英) Anesthetics, Inhalation (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Ethidium (日) (読) [継承]
5. (英) Fluorescent Dyes (日) (読) [継承]
6. (英) Free Radical Scavengers (日) (読) [継承]
7. (英) Hemodynamics (日) (読) [継承]
8. (英) Ion Channel Gating (日) (読) [継承]
9. (英) Ischemic Preconditioning, Myocardial (日) (読) [継承]
10. (英) Isoflurane (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Microscopy, Confocal (日) (読) [継承]
13. (英) Mitochondria, Heart (日) (読) [継承]
14. (英) Myocardial Infarction (日) (読) [継承]
15. (英) Myocardium (日) (読) [継承]
16. (英) Potassium Channels (日) (読) [継承]
17. (英) Pulmonary Alveoli (日) (読) [継承]
18. (英) Rabbits (日) (読) [継承]
19. (英) Reactive Oxygen Species (日) (読) [継承]
発行所 (推奨): The American Society of Anesthesiologists [継承]
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2003年 4月 初日 (平成 15年 4月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/30009128458/ [継承]
DOI (任意): 10.1097/00000542-200304000-00021    (→Scopusで検索) [継承]
PMID (任意): 12657856    (→Scopusで検索) [継承]
NAID (任意): 30009128458 [継承]
WOS (任意): 000181865500020 [継承]
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評価値 (任意):
被引用数 (任意): 4 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Katsuya Tanaka, D Weihrauch, LM Ludwig, JR Kersten, PS Pagel and DC Warltier : Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species., Anesthesiology, Vol.98, No.4, 935-43, 2003.
欧文冊子 ● Katsuya Tanaka, D Weihrauch, LM Ludwig, JR Kersten, PS Pagel and DC Warltier : Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species., Anesthesiology, Vol.98, No.4, 935-43, 2003.

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