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EID=94646EID:94646, Map:0, LastModified:2018年12月3日(月) 13:43:03, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[田中 克哉], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.Medical College of Wisconsin [継承]
著者 (必須): 1.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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2. (英) Weihrauch D (日) (読)
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[継承]
3. (英) Kehl F (日) (読)
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4. (英) Ludwig LM (日) (読)
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5. (英) LaDisa JF (日) (読)
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[継承]
6. (英) Kersten JR (日) (読)
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7. (英) Pagel PS (日) (読)
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8. (英) Warltier DC (日) (読)
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題名 (必須): (英) Mechanism of preconditioning by isoflurane in rabbits  (日)    [継承]
副題 (任意): (英) A direct role for reactive oxygen species  (日)    [継承]
要約 (任意): (英) Reactive oxygen species (ROS) contribute to myocardial protection during ischemic preconditioning, but the role of the ROS in protection against ischemic injury produced by volatile anesthetics has only recently been explored. We tested the hypothesis that ROS mediate isoflurane-induced preconditioning in vivo. Pentobarbital-anesthetized rabbits were instrumented for measurement of hemodynamics and were subjected to a 30 min coronary artery occlusion followed by 3 h reperfusion. Rabbits were randomly assigned to receive vehicle (0.9% saline), or the ROS scavengers N-acetylcysteine (NAC; 150 mg/kg) or N-2-mercaptopropionyl glycine (2-MPG; 1 mg. kg(-1).min(-1)), in the presence or absence of 1.0 minimum alveolar concentration (MAC) isoflurane. Isoflurane was administered for 30 min and then discontinued 15 min before coronary artery occlusion. A fluorescent probe for superoxide anion production (dihydroethidium, 2 mg) was administered in the absence of the volatile anesthetic or 5 min before exposure to isoflurane in 2 additional groups (n = 8). Myocardial infarct size and superoxide anion production were assessed using triphenyltetrazolium staining and confocal fluorescence microscopy, respectively. Isoflurane (P < 0.05) decreased infarct size to 24 +/- 4% (mean +/- SEM; n = 10) of the left ventricular area at risk compared with control experiments (43 +/- 3%; n = 8). NAC (43 +/- 3%; n = 7) and 2-MPG (42 +/- 5%; n = 8) abolished this beneficial effect, but had no effect on myocardial infarct size (47 +/- 3%; n = 8 and 46 +/- 3; n = 7, respectively) when administered alone. Isoflurane increased superoxide anion production as compared with control experiments (28 +/- 12 -6 +/- 9 fluorescence units; P < 0.05). The results indicate that ROS produced following administration of isoflurane contribute to protection against myocardial infarction in vivo.  (日)    [継承]
キーワード (推奨): 1. (英) Analysis of Variance (日) (読) [継承]
2. (英) Anesthetics, Inhalation (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Hemodynamics (日) (読) [継承]
5. (英) Isoflurane (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Myocardial Infarction (日) (読) [継承]
8. (英) Rabbits (日) (読) [継承]
9. (英) Reactive Oxygen Species (日) (読) [継承]
発行所 (推奨): The American Society of Anesthesiologists [継承]
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1485 90 [継承]
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年月日 (必須): 西暦 2002年 12月 初日 (平成 14年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1097/00000542-200212000-00021    (→Scopusで検索) [継承]
PMID (任意): 12459675    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0036895112 [継承]
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被引用数 (任意): 13 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Katsuya Tanaka, D Weihrauch, F Kehl, LM Ludwig, JF LaDisa, JR Kersten, PS Pagel and DC Warltier : Mechanism of preconditioning by isoflurane in rabbits, --- A direct role for reactive oxygen species ---, Anesthesiology, Vol.97, No.6, 1485-90, 2002.
欧文冊子 ● Katsuya Tanaka, D Weihrauch, F Kehl, LM Ludwig, JF LaDisa, JR Kersten, PS Pagel and DC Warltier : Mechanism of preconditioning by isoflurane in rabbits, --- A direct role for reactive oxygen species ---, Anesthesiology, Vol.97, No.6, 1485-90, 2002.

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