| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | Medical College of Wisconsin
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| ○著者 (必須): | 1. | 田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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| ○学籍番号 (推奨): |
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| 2. | (英) Kehl Franz (日) (読)
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| 3. | (英) Gu Weidong (日) (読)
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| 4. | (英) Krolilowski G. John (日) (読)
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| ○学籍番号 (推奨): |
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| 5. | (英) Pagel S. Paul (日) (読)
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| 6. | (英) Warltier C. David (日) (読)
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| 7. | (英) Kersten R. Judy (日) (読)
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| ○題名 (必須): | □ | (英) Isoflurane-induced preconditioning is attenuated by diabetes. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Volatile anesthetics stimulate, but hyperglycemia attenuates, the activity of mitochondrial ATP-regulated K(+) channels. We tested the hypothesis that diabetes mellitus interferes with isoflurane-induced preconditioning. Acutely instrumented, barbiturate-anesthetized dogs were randomly assigned to receive 0, 0.32, or 0.64% end-tidal concentrations of isoflurane in the absence or presence of diabetes (3 wk after administration of alloxan and streptozotocin) in six experimental groups. All dogs were subjected to a 60-min left anterior descending coronary artery occlusion followed by 3 h of reperfusion. Myocardial infarct size (triphenyltetrazolium staining) was 29 +/- 3% (n = 8) of the left ventricular area at risk in control experiments. Isoflurane reduced infarct size (15 +/- 2 and 13 +/- 1% during 0.32 and 0.64% concentrations; n = 8 and 7 dogs, respectively). Diabetes alone did not alter infarct size (30 +/- 3%; n = 8) but blocked the protective effects of 0.32% (27 +/- 2%; n = 7) and not 0.64% isoflurane (18 +/- 3%; n = 7). Infarct size was directly related to blood glucose concentrations in diabetic dogs, but this relationship was abolished by higher concentrations of isoflurane. The results indicate that blood glucose and end-tidal isoflurane concentrations are important determinants of infarct size during anesthetic-induced preconditioning. (日)
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| ○キーワード (推奨): | 1. | (英) Anesthetics, Inhalation (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Blood Glucose (日) (読)
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| 4. | (英) Constriction (日) (読)
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| 5. | (英) Coronary Vessels (日) (読)
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| 6. | (英) Diabetes Mellitus, Experimental (日) (読)
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| 7. | (英) Dogs (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Ischemic Preconditioning (日) (読)
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| 10. | (英) Isoflurane (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Myocardial Infarction (日) (読)
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| 13. | 心筋虚血 (myocardial ischemia)
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| 14. | (英) Myocardial Reperfusion Injury (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | American Journal of Physiology, Heart and Circulatory Physiology ([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)
| ○ISSN (任意): | □ | 0363-6135
ISSN: 0363-6135
(pISSN: 0363-6135, eISSN: 1522-1539) Title: American journal of physiology. Heart and circulatory physiologyTitle(ISO): Am J Physiol Heart Circ PhysiolPublisher: American Physiological Society (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 282
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | H2018 H2023
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2002年 6月 初日 (平成 14年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1152/ajpheart.01130.2001 (→Scopusで検索)
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| ○PMID (任意): | □ | 12003806 (→Scopusで検索)
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| ○WOS (任意): |
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| ○評価値 (任意): |
| ○被引用数 (任意): | □ | 2
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Anesthesiology, Milwaukee, Wisconsin 53226. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S. (日)
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