『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=94645)

EID=94645EID:94645, Map:0, LastModified:2013年6月28日(金) 14:34:43, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[田中 克哉], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.Medical College of Wisconsin [継承]
著者 (必須): 1.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kehl Franz (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Gu Weidong (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Krolilowski G. John (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Pagel S. Paul (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Warltier C. David (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Kersten R. Judy (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Isoflurane-induced preconditioning is attenuated by diabetes.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Volatile anesthetics stimulate, but hyperglycemia attenuates, the activity of mitochondrial ATP-regulated K(+) channels. We tested the hypothesis that diabetes mellitus interferes with isoflurane-induced preconditioning. Acutely instrumented, barbiturate-anesthetized dogs were randomly assigned to receive 0, 0.32, or 0.64% end-tidal concentrations of isoflurane in the absence or presence of diabetes (3 wk after administration of alloxan and streptozotocin) in six experimental groups. All dogs were subjected to a 60-min left anterior descending coronary artery occlusion followed by 3 h of reperfusion. Myocardial infarct size (triphenyltetrazolium staining) was 29 +/- 3% (n = 8) of the left ventricular area at risk in control experiments. Isoflurane reduced infarct size (15 +/- 2 and 13 +/- 1% during 0.32 and 0.64% concentrations; n = 8 and 7 dogs, respectively). Diabetes alone did not alter infarct size (30 +/- 3%; n = 8) but blocked the protective effects of 0.32% (27 +/- 2%; n = 7) and not 0.64% isoflurane (18 +/- 3%; n = 7). Infarct size was directly related to blood glucose concentrations in diabetic dogs, but this relationship was abolished by higher concentrations of isoflurane. The results indicate that blood glucose and end-tidal isoflurane concentrations are important determinants of infarct size during anesthetic-induced preconditioning.  (日)    [継承]
キーワード (推奨): 1. (英) Anesthetics, Inhalation (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blood Glucose (日) (読) [継承]
4. (英) Constriction (日) (読) [継承]
5. (英) Coronary Vessels (日) (読) [継承]
6. (英) Diabetes Mellitus, Experimental (日) (読) [継承]
7. (英) Dogs (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Ischemic Preconditioning (日) (読) [継承]
10. (英) Isoflurane (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Myocardial Infarction (日) (読) [継承]
13.心筋虚血 (myocardial ischemia) [継承]
14. (英) Myocardial Reperfusion Injury (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology, Heart and Circulatory Physiology ([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)

ISSN (任意): 0363-6135
ISSN: 0363-6135 (pISSN: 0363-6135, eISSN: 1522-1539)
Title: American journal of physiology. Heart and circulatory physiology
Title(ISO): Am J Physiol Heart Circ Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 282 [継承]
(必須): 6 [継承]
(必須): H2018 H2023 [継承]
都市 (任意):
年月日 (必須): 西暦 2002年 6月 初日 (平成 14年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1152/ajpheart.01130.2001    (→Scopusで検索) [継承]
PMID (任意): 12003806    (→Scopusで検索) [継承]
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評価値 (任意):
被引用数 (任意): 2 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, Milwaukee, Wisconsin 53226.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Katsuya Tanaka, Franz Kehl, Weidong Gu, John G. Krolilowski, Paul S. Pagel, David C. Warltier and Judy R. Kersten : Isoflurane-induced preconditioning is attenuated by diabetes., American Journal of Physiology, Heart and Circulatory Physiology, Vol.282, No.6, H2018-H2023, 2002.
欧文冊子 ● Katsuya Tanaka, Franz Kehl, Weidong Gu, John G. Krolilowski, Paul S. Pagel, David C. Warltier and Judy R. Kersten : Isoflurane-induced preconditioning is attenuated by diabetes., American Journal of Physiology, Heart and Circulatory Physiology, Vol.282, No.6, H2018-H2023, 2002.

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