『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=93861EID:93861, Map:0, LastModified:2013年8月12日(月) 16:44:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[医学部·歯学部附属病院長]/[徳島大学.病院]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
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組織 (推奨): 1.徳島大学.病院.診療科.内科 (2003年10月1日〜) [継承]
著者 (必須): 1. (英) Oki Takashi (日) 大木 崇 (読) おおき たかし
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2. (英) Fukuda Nobuo (日) 福田 信夫 (読) ふくだ のぶお
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3. (英) Iuchi Arata (日) 井内 新 (読) いうち あらた
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4.田畑 智継
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5. (英) Sasaki Miwa (日) 佐々木 美和 (読) ささき みわ
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題名 (必須): (英) Effects of enalapril on left ventricular mass and diastolic function in essential hypertension: special reference to duration of hypertension.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Using M-mode and pulsed Doppler echocardiography, the effects of enalapril on left ventricular (LV) hypertrophy and diastolic dysfunction in essential hypertension and the relation between improvement in these two parameters and duration of hypertension were evaluated. The subjects, 30 previously untreated hypertensive patients, were divided into nonhypertrophy (18 patients) and hypertrophy (12 patients) groups. All patients received enalapril at a daily dose of 5 to 10 mg for 6 months. Left ventricular mass by M-mode echocardiography and LV inflow (LVIF) velocity by transthoracic pulsed Doppler echocardiography were measured before and after enalapril therapy. In the nonhypertrophy group, enalapril significantly increased peak early diastolic LVIF (E) velocity (P < .05), slightly lowered peak atrial systolic LVIF (A) velocity, significantly decreased their ratio (A/E) (P < .01), and significantly shortened both the deceleration time, from the peak of the early diastolic wave, and isovolumic relaxation time (P < .05 and P < .01, respectively). In the hypertrophy group, enalapril significantly increased E (P < .05), slightly lowered A, significantly decreased A/E (P < .05), slightly shortened the deceleration time and isovolumic relaxation time, and slightly decreased LV mass. The administration of enalapril correlated significantly and positively with the duration of hypertension and the rates of change in A/E and LV mass in all of the hypertensive patients (P < .01 and P < .05, respectively). These results suggest that long-term administration of enalapril to hypertensive patients improves LV diastolic hemodynamics regardless of the presence or absence of LV hypertrophy and that the effects are most remarkable in patients with the shortest duration of hypertension.  (日)    [継承]
キーワード (推奨): 1. (英) Angiotensin-Converting Enzyme Inhibitors (日) (読) [継承]
2. (英) Antihypertensive Agents (日) (読) [継承]
3. (英) Blood Flow Velocity (日) (読) [継承]
4. (英) Enalapril (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Heart Ventricles (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Hypertension (日) (読) [継承]
9. (英) Hypertrophy, Left Ventricular (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
発行所 (推奨): Elsevier Science Inc. USA [継承]
誌名 (必須): Journal of Cardiac Failure (Heart Failure Society of America/Japanese Heart Failure Society)
(pISSN: 1071-9164, eISSN: 1532-8414)

ISSN (任意): 1071-9164
ISSN: 1071-9164 (pISSN: 1071-9164, eISSN: 1532-8414)
Title: Journal of cardiac failure
Title(ISO): J Card Fail
Publisher: Churchill Livingstone
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1 [継承]
(必須): 5 [継承]
(必須): 365 370 [継承]
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年月日 (必須): 西暦 1995年 12月 初日 (平成 7年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/S1071-9164(05)80005-3    (→Scopusで検索) [継承]
PMID (任意): 12836711    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Internal Medicine, Tokushima University School of Medicine, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata and Miwa Sasaki : Effects of enalapril on left ventricular mass and diastolic function in essential hypertension: special reference to duration of hypertension., Journal of Cardiac Failure, Vol.1, No.5, 365-370, 1995.
欧文冊子 ● Takashi Oki, Nobuo Fukuda, Arata Iuchi, Tomotsugu Tabata and Miwa Sasaki : Effects of enalapril on left ventricular mass and diastolic function in essential hypertension: special reference to duration of hypertension., Journal of Cardiac Failure, Vol.1, No.5, 365-370, 1995.

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