『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=93523EID:93523, Map:0, LastModified:2015年3月25日(水) 11:07:58, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.森田 恭二
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2.石村 和敬
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3. (英) Tsuruo Yoshihiro (日) (読)
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4. (英) Wong L. Dona (日) (読)
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題名 (必須): (英) Dexamethasone enhances serum deprivation-induced necrotic death of rat C6 glioma cells through activation of glucocorticoid receptors  (日)    [継承]
副題 (任意):
要約 (任意): (英) Glucocorticoids have been shown to be neurotoxic and appear to play a role in neuronal cell loss during aging and following neuropathological insults. However, very little is known about the effects of these steroid hormones on glial cells. The effect of the synthetic glucocorticoid dexamethasone (DEX) on glial cell viability was therefore examined by measuring neutral red uptake into rat C6 glioma cells. Serum deprivation markedly reduced cell viability, and this effect was significantly enhanced by DEX. Electrophoretic analysis showed that the cell damage induced by either serum deprivation alone or in combination with DEX was not accompanied by the degradation of DNA into nucleosomic fragments. Electron microscopic studies confirmed that serum deprivation and glucocorticoid treatment caused necrotic cell death. Furthermore, the effect of DEX on cell viability could be mimicked by the glucocorticoid receptor agonist RU28362, and completely prevented by the glucocorticoid receptor antagonist RU38486. These results indicate that dexamethasone can enhance the necrotic death of glioma cells induced by serum deprivation, suggesting that glucocorticoids may be involved in the chronic alteration of brain function arising from neuropathological damage to glial cells.  (日)    [継承]
キーワード (推奨): 1. (英) Androstanols (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Survival (日) (読) [継承]
4. (英) Culture Media, Serum-Free (日) (読) [継承]
5. (英) DNA, Neoplasm (日) (読) [継承]
6. (英) Dexamethasone (日) (読) [継承]
7. (英) Glioma (日) (読) [継承]
8. (英) Glucocorticoids (日) (読) [継承]
9. (英) Microscopy, Electron (日) (読) [継承]
10. (英) Necrosis (日) (読) [継承]
11. (英) Neuroglia (日) (読) [継承]
12. (英) Neurons (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Receptors, Glucocorticoid (日) (読) [継承]
15. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Brain Research ([Elsevier Science])
(pISSN: 0006-8993, eISSN: 1872-6240)

ISSN (任意): 0006-8993
ISSN: 0006-8993 (pISSN: 0006-8993, eISSN: 1872-6240)
Title: Brain research
Title(ISO): Brain Res.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 309 316 [継承]
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年月日 (必須): 西暦 1999年 1月 23日 (平成 11年 1月 23日) [継承]
URL (任意):
DOI (任意): 10.1016/S0006-8993(98)01093-2    (→Scopusで検索) [継承]
PMID (任意): 9878804    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000078140100006 [継承]
Scopus (任意): 2-s2.0-0033596505 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Kazunori Ishimura, Yoshihiro Tsuruo and Dona L. Wong : Dexamethasone enhances serum deprivation-induced necrotic death of rat C6 glioma cells through activation of glucocorticoid receptors, Brain Research, Vol.816, No.2, 309-316, 1999.
欧文冊子 ● Kyoji Morita, Kazunori Ishimura, Yoshihiro Tsuruo and Dona L. Wong : Dexamethasone enhances serum deprivation-induced necrotic death of rat C6 glioma cells through activation of glucocorticoid receptors, Brain Research, Vol.816, No.2, 309-316, 1999.

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