『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=93153)

EID=93153EID:93153, Map:0, LastModified:2012年11月5日(月) 16:19:44, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[香川 征], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.岡 夏生
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2.奥村 裕司
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3.金山 博臣 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学])
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4.井崎 博文
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5. (英) Okamoto Masumi (日) (読)
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6.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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7.香川 征
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題名 (必須): (英) Amiloride and Urinary Trypsin Inhibitor Inhibit Urothelial Cancer Invasion  (日)    [継承]
副題 (任意):
要約 (任意): (英) To determine the contribution of urokinase-type plasminogen activator (uPA) and plasmin in the invasion of highly invasive urothelial cancer cells. We compared expression levels of mRNA and protease activity of uPA and plasmin formation in primary cultures of the noninvasive transitional cell carcinoma, UCT-1, and in the highly invasive type, UCT-2. By using in vitro cell invasion assay system, we evaluated the effects of amiloride and urinary trypsin inhibitor (UTI), which inhibit uPA and plasmin, respectively, on invasion by both cell lines. Expression levels of mRNA, protein, and activities of uPA were significantly higher (p<0.005) and resulted in more plasminogen activation in UCT-2 than in UCT-1. Amiloride and UTI significantly inhibited plasmin formation and the invasion of both cell lines (p<0.001). High expression levels of mRNA, activities of uPA and high plasmin formation significantly potentiated the invasiveness of urothelial cancer cells. Thus, inhibitors of uPA and plasmin, such as amiloride and UTI, respectively, could be useful therapeutic tools with which to treat urothelial cancer.  (日)    [継承]
キーワード (推奨): 1. (英) Amiloride (日) (読) [継承]
2. (英) Carcinoma, Transitional Cell (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Neoplasm Invasiveness (日) (読) [継承]
9. (英) RNA, Messenger (日) (読) [継承]
10. (英) Sensitivity and Specificity (日) (読) [継承]
11. (英) Trypsin Inhibitors (日) (読) [継承]
12. (英) Urokinase-Type Plasminogen Activator (日) (読) [継承]
13. (英) Urothelium (日) (読) [継承]
発行所 (推奨):
誌名 (必須): European Urology (European Association of Urology)
(pISSN: 0302-2838, eISSN: 1873-7560)

ISSN (任意): 0302-2838
ISSN: 0302-2838 (pISSN: 0302-2838, eISSN: 1873-7560)
Title: European urology
Title(ISO): Eur Urol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 44 [継承]
(必須): 6 [継承]
(必須): 737 741 [継承]
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年月日 (必須): 西暦 2003年 12月 初日 (平成 15年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/S0302-2838(03)00383-X    (→Scopusで検索) [継承]
PMID (任意): 14644129    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Urology, The University of Tokushima School of Medicine, 3-18-15, Kuramoto-Cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Natsuo Oka, Yuushi Okumura, Hiro-omi Kanayama, Hirofumi Izaki, Masumi Okamoto, Hiroshi Kido and Susumu Kagawa : Amiloride and Urinary Trypsin Inhibitor Inhibit Urothelial Cancer Invasion, European Urology, Vol.44, No.6, 737-741, 2003.
欧文冊子 ● Natsuo Oka, Yuushi Okumura, Hiro-omi Kanayama, Hirofumi Izaki, Masumi Okamoto, Hiroshi Kido and Susumu Kagawa : Amiloride and Urinary Trypsin Inhibitor Inhibit Urothelial Cancer Invasion, European Urology, Vol.44, No.6, 737-741, 2003.

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