『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=92196)

EID=92196EID:92196, Map:0, LastModified:2016年7月5日(火) 20:13:07, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[北畑 洋], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部.医学科.病態情報医学講座 [継承]
2.附属病院 (〜2003年9月30日/->組織[徳島大学.病院.医科診療部門]) [継承]
著者 (必須): 1.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.大下 修造
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kimura Hideyuki (日) 木村 英之 (読) きむら ひでゆき
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.川人 伸次 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Park Y-C (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Sakabe Takeshi (日) 坂部 武史 (読) さかべ たけし
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Effects of nicardipine on ventriculo-arterial coupling in humans.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The ratio of effective arterial elastance (Ea) to left ventricular elastance (Ees) is an indicator of the coupling between ventricular properties and arterial load properties. Another criterion for the coupling between an energy source and its load is the principle of economical fuel consumption, or mechanical efficiency, which is defined as the ratio of stroke work (SW) to myocardial oxygen consumption per beat (MVO2). It has been revealed that SW of ventricular contraction is maximized when Ea/Ees = 1, while mechanical efficiency is maximized when Ea/Ees = 0.5. The purpose of the present study was to investigate the ventriculo-arterial coupling during hypertension, and the effects of nicardipine on this relationship in surgical patients using Ea/Ees and SW/MVO2 as indicators. Anaesthesia was maintained with isoflurane, nitrous oxide, and fentanyl. Radial artery pressure was displayed on a polygraph, and left ventricular end-systolic and end-diastolic volumes were determined by use of transoesophageal echocardiography. Ees was calculated as MAP/(ESVI-4), where MAP is mean arterial pressure and ESVI is end-systolic volume index. Ea was calculated as the ratio of MAP to stroke volume index (SVI). Stroke work index (SWI) was calculated as the product of MAP and SVI. MVO2 was assessed by estimating the ventricular pressure-volume area index (PVAI), which is expressed as the sum of SWI and the end-systolic potential energy index. Before (baseline), and 3, 10, 20, and 30 min after i.v. nicardipine (30 micrograms kg-1), Ea/Ees and SWI/PVAI were determined in 14 surgical patients with intraoperative hypertension. Before nicardipine (during hypertension), Ea was almost equal to Ees, whereas Ea/Ees was significantly reduced to about 0.5-0.6 at 3, 10, and 20 min after nicardipine. SWI/PVAI was maximized and significantly greater than the baseline value at 3 min after nicardipine. These results suggest that, during hypertension, ventricular and arterial properties were so matched as to maximize SW at the expense of the work efficiency, whereas mechanical efficiency of ventricular contraction was maximized after nicardipine.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Anesthetics, Inhalation (日) (読) [継承]
3. (英) Antihypertensive Agents (日) (読) [継承]
4. (英) Blood Pressure (日) (読) [継承]
5. (英) Dose-Response Relationship, Drug (日) (読) [継承]
6. (英) Elasticity (日) (読) [継承]
7. (英) Feedback (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Hemodynamics (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Hypertension (日) (読) [継承]
12. (英) Isoflurane (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Middle Aged (日) (読) [継承]
15. (英) Nicardipine (日) (読) [継承]
16. (英) Pulmonary Artery (日) (読) [継承]
17. (英) Stroke Volume (日) (読) [継承]
18. (英) Ventricular Function, Left (日) (読) [継承]
発行所 (推奨):
誌名 (必須): British Journal of Anaesthesia ([Oxford University Press])
(pISSN: 0007-0912, eISSN: 1471-6771)

ISSN (任意): 0007-0912
ISSN: 0007-0912 (pISSN: 0007-0912, eISSN: 1471-6771)
Title: British journal of anaesthesia
Title(ISO): Br J Anaesth
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 81 [継承]
(必須): 2 [継承]
(必須): 180 185 [継承]
都市 (任意):
年月日 (必須): 西暦 1998年 8月 初日 (平成 10年 8月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 9813519    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Katsuya Tanaka, Shuzo Oshita, Hiroshi Kitahata, Hideyuki Kimura, Shinji Kawahito, Y-C Park and Takeshi Sakabe : Effects of nicardipine on ventriculo-arterial coupling in humans., British Journal of Anaesthesia, Vol.81, No.2, 180-185, 1998.
欧文冊子 ● Katsuya Tanaka, Shuzo Oshita, Hiroshi Kitahata, Hideyuki Kimura, Shinji Kawahito, Y-C Park and Takeshi Sakabe : Effects of nicardipine on ventriculo-arterial coupling in humans., British Journal of Anaesthesia, Vol.81, No.2, 180-185, 1998.

関連情報

Number of session users = 0, LA = 1.27, Max(EID) = 360814, Max(EOID) = 966431.