『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.徳島大学.医学部.医学科.病態情報医学講座 [継承]
2.附属病院 (〜2003年9月30日/->組織[徳島大学.病院.医科診療部門]) [継承]
著者 (必須): 1. (英) Hirose Yoshiaki (日) 廣瀬 嘉明 (読) ひろせ よしあき
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2. (英) Kimura Hideyuki (日) 木村 英之 (読) きむら ひでゆき
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3.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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4.川人 伸次 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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5.大下 修造
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題名 (必須): (英) Nitric oxide does not play a major role in the regulation of systemic hemodynamic responses to acute normovolemic hemodilution.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The mechanisms of cardiovascular changes following acute normovolemic hemodilution (ANH) have not been fully elucidated. We tested the hypothesis that inhibition of nitric oxide synthesis attenuates ANH-induced cardiovascular responses. We observed the effects of N(omega)-nitro-L-arginine methyl ester (L-NAME) pretreatment on ANH-induced cardiovascular responses and compared these effects with those elicited by phenylephrine (PHE). Twenty dogs anesthetized with isoflurane were divided into two groups: one group was pretreated with L-NAME and the other with PHE. Both groups were normovolemically hemodiluted using 6% hydroxyethyl starch to reduce the hemoglobin concentration to approximately 50% of the pretreatment value. Pretreatment with either L-NAME or PHE caused a significant increase in mean aortic blood pressure (MAP) and systemic vascular resistance (SVR) with a significant decrease in cardiac output (CO) and stroke volume (SV). However, no remarkable differences in these variables were seen between groups. In both groups ANH produced increases in heart rate, CO, SV, and maximal left ventricular dP/dt with a significant decrease in SVR. No significant differences in these variables were apparent after ANH except that MAP was decreased in the PHE group but not in the L-NAME group. Our results suggest that nitric oxide does not play a major role in mediation or modulation of the systemic vascular responses to ANH.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Dogs (日) (読) [継承]
3. (英) Enzyme Inhibitors (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Hemodilution (日) (読) [継承]
6. (英) Hemodynamics (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) NG-Nitroarginine Methyl Ester (日) (読) [継承]
9. (英) Nitric Oxide (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Acta Anaesthesiologica Scandinavica (Nordisk anaestesiologisk forening/Scandinavian Society of Anaesthesiology and Intensive Care Medicine)
(pISSN: 0001-5172, eISSN: 1399-6576)

ISSN (任意): 0001-5172
ISSN: 0001-5172 (pISSN: 0001-5172, eISSN: 1399-6576)
Title: Acta anaesthesiologica Scandinavica
Title(ISO): Acta Anaesthesiol Scand
Supplier: Scandinavian Society of Anaesthesiology and Intensive Care Medicine
Publisher: Blackwell
 (NLM Catalog  (Wiley  (CrossRef (Scopus information is found. [need login])
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(必須): 44 [継承]
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(必須): 96 100 [継承]
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年月日 (必須): 西暦 2000年 1月 初日 (平成 12年 1月 初日) [継承]
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DOI (任意): 10.1034/j.1399-6576.2000.440117.x    (→Scopusで検索) [継承]
PMID (任意): 10669279    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

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和文冊子 ● Yoshiaki Hirose, Hideyuki Kimura, Hiroshi Kitahata, Shinji Kawahito and Shuzo Oshita : Nitric oxide does not play a major role in the regulation of systemic hemodynamic responses to acute normovolemic hemodilution., Acta Anaesthesiologica Scandinavica, Vol.44, No.1, 96-100, 2000.
欧文冊子 ● Yoshiaki Hirose, Hideyuki Kimura, Hiroshi Kitahata, Shinji Kawahito and Shuzo Oshita : Nitric oxide does not play a major role in the regulation of systemic hemodynamic responses to acute normovolemic hemodilution., Acta Anaesthesiologica Scandinavica, Vol.44, No.1, 96-100, 2000.

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