『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.橋本 あい子 (->個人[山内 あい子])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kawada J (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) Insulin encapsulated in liposomes of various lipid compositions were prepared. The amount of insulin trapped in these liposomes increased in the order, negatively charged liposomes less than neutral liposomes less than positively charged liposomes. In positively charged liposomes, the amount of insulin trapped increased with increase in the amount of amphiphile stearylamine. Under the conditions tested, the highest insulin content (about 50%) was obtained with liposomes composed of phosphatidyl choline/cholesterol/stearylamine in a molar ratio of 7/2/2.25. These liposomes were stable on incubation for 3 hr at 37 degrees C in solutions of pepsin, trypsin, and pancreatin, and after these incubations, a considerable amount of insulin was still associated with the liposomes. However, the liposomes released almost all the insulin into the medium on treatment with bile. When the liposomes were administered orally to rats in the 3rd phase of acute alloxan diabetes, reduction of the blood glucose level was observed in 7 of 11 animals, the reduction persisted for several hours and was ranging from 30 to 75%. In alloxan diabetic rats showing hyperglycemia for 3 to 6 months, the liposomes also increased the glucose tolerance in half the animals tested.  (日)    [継承]
キーワード (推奨): 1. (英) Administration, Oral (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blood Glucose (日) (読) [継承]
4. (英) Chronic Disease (日) (読) [継承]
5. (英) Diabetes Mellitus, Experimental (日) (読) [継承]
6. (英) Drug Stability (日) (読) [継承]
7. (英) Glucose Tolerance Test (日) (読) [継承]
8.インスリン (insulin) [継承]
9.リポソーム (liposomes) [継承]
10.男性 (male) [継承]
11. (英) Rats (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinologia Japonica ([社団法人 日本内分泌学会])
(pISSN: 0013-7219, eISSN: 2185-6370)

ISSN (任意): 0013-7219
ISSN: 0013-7219 (pISSN: 0013-7219, eISSN: 2185-6370)
Title: Endocrinologia japonica
Title(ISO): Endocrinol Jpn
Supplier: 一般社団法人 日本内分泌学会
Publisher: Endocrine Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 26 [継承]
(必須): 3 [継承]
(必須): 337 344 [継承]
都市 (任意):
年月日 (必須): 西暦 1979年 1月 初日 (昭和 54年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1507/endocrj1954.26.337    (→Scopusで検索) [継承]
PMID (任意): 477621    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-0018718071 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Aiko Hashimoto and J Kawada : Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats, Endocrinologia Japonica, Vol.26, No.3, 337-344, 1979.
欧文冊子 ● Aiko Hashimoto and J Kawada : Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats, Endocrinologia Japonica, Vol.26, No.3, 337-344, 1979.

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