『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体情報薬科学部門.分子情報薬学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.柴田 瑩
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2. (英) Ikema H. (日) (読)
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3.植野 哲 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.総合薬学教育学系.総合薬学研究推進学])
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4. (英) Muneyuki E. (日) (読)
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5.樋口 富彦
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題名 (必須): (英) Alkane derivative-bacteriorhodopsin interaction: proton transport and protein structure  (日)    [継承]
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要約 (任意): (英) The effects of alkane derivatives, 1-alcohols (ROH), aliphatic amine hydrochlorides (RNH(2).HCl) and sodium aliphatic carboxylates (ROONa), on the proton pumping activity of bacteriorhodopsin (bR) in a purple membrane have been examined. Photocurrents in bR in the purple membrane adsorbed onto polyester thin film were recorded before and after exposure to these test substances. The peak photocurrent in bR was reversibly suppressed by each substance. From the dose-response curve, the concentrations required to reduce the peak capacitive current by 50% were determined for each homolog and then the standard free energies per CH(2) for the adsorption of the alkane derivatives to the site of action were estimated: -3.13 kJ mol(-1) for ROH, -3.05 kJ mol(-1) for RNH(3)(+), and -2.95 kJ mol(-1) for ROO(-). The proton pumping activity of bR was mainly suppressed by the hydrophobic interaction with the additive. The relative potencies of the functional groups of the alkane derivatives were almost comparable between 1-octanol (C(8)OH) and octylamine hydrochloride (C(8)NH(3)(+)) and about 10 times less effective for sodium octanoate (C(8)OO(-)) than for others. The addition of C(8)OH or C(8)OO(-) changed the absorption spectra of bR with a maximum at 560 nm to the spectra of the intermediate state with a maximum at 480 nm, while the C(8)NH(3)(+) decreased the intensity of the 560 nm band only with no blue-shift by the 480 nm band. We conclude that the action of the alkane derivatives is nonspecific and directed to all organized purple membrane structures and that the binding sites of the ROH and ROO(-) are different from that of RNH(3)(+).  (日)    [継承]
キーワード (推奨): 1. (英) Bacteriorhodopsin (日) (読) [継承]
2. (英) Photocurrent (日) (読) [継承]
3. (英) Alkane derivatives (日) (読) [継承]
4. (英) Fluorescence spectrum (日) (読) [継承]
5. (英) Absorption spectrum (日) (読) [継承]
発行所 (推奨): Elsevier Science B.V. [継承]
誌名 (必須): Colloids and Surfaces B:Biointerfaces ([Elsevier])
(pISSN: 0927-7765, eISSN: 1873-4367)

ISSN (任意): 1873-4367
ISSN: 0927-7765 (pISSN: 0927-7765, eISSN: 1873-4367)
Title: Colloids and surfaces. B, Biointerfaces
Title(ISO): Colloids Surf B Biointerfaces
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2001年 9月 初日 (平成 13年 9月 初日) [継承]
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DOI (任意): 10.1016/S0927-7765(01)00155-2    (→Scopusで検索) [継承]
PMID (任意): 11438238    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0034955467 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Akira Shibata, H. Ikema, Satoru Ueno, E. Muneyuki and Tomihiko Higuti : Alkane derivative-bacteriorhodopsin interaction: proton transport and protein structure, Colloids and Surfaces B:Biointerfaces, Vol.22, No.1, 31-38, 2001.
欧文冊子 ● Akira Shibata, H. Ikema, Satoru Ueno, E. Muneyuki and Tomihiko Higuti : Alkane derivative-bacteriorhodopsin interaction: proton transport and protein structure, Colloids and Surfaces B:Biointerfaces, Vol.22, No.1, 31-38, 2001.

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