『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=90840)

EID=90840EID:90840, Map:0, LastModified:2018年12月3日(月) 13:33:25, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[北畑 洋], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部.医学科.病態情報医学講座 [継承]
2.特殊栄養学講座 (〜2004年3月31日/->組織[徳島大学.医学部.医科栄養学科.臨床実践栄養学講座.代謝栄養学]) [継承]
著者 (必須): 1. (英) Tsutsumi Yasuo (日) 堤 保夫 (読) つつみ やすお
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.大下 修造
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kawano Takashi (日) 河野 崇 (読) かわの たかし
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.富山 芳信 ([徳島大学.病院.中央診療施設等.手術部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Kuroda Yasuhiro (日) 黒田 泰弘 (読) くろだ やすひろ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.中屋 豊
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Accumulating evidence suggests that mitochondrial rather than sarcolemmal adenosine triphosphate-sensitive K+ (K(ATP)) channels may have an important role in the protection of myocardium during ischemia. Because both lidocaine and mexiletine are frequently used antiarrhythmic drugs during myocardial ischemia, it is important to investigate whether they affect mitochondrial K(ATP) channel activities. Male Wistar rats were anesthetized with ether. Single, quiescent ventricular myocytes were dispersed enzymatically. The authors measured flavoprotein fluorescence to evaluate mitochondrial redox state. Lidocaine or mexiletine was applied after administration of diazoxide (25 microM), a selective mitochondrial K(ATP) channel opener. The redox signal was normalized to the baseline flavoprotein fluorescence obtained during exposure to 2,4-dinitrophenol, a protonophore that uncouples respiration from ATP synthesis and collapses the mitochondrial potential. Diazoxide-induced oxidation of flavoproteins and the redox changes were inhibited by 5-hydroxydecanoic acid, a selective mitochondrial K(ATP) channel blocker, suggesting that flavoprotein fluorescence can be used as an index of mitochondrial oxidation mediated by mitochondrial K(ATP) channels. Lidocaine (10(-3) to 10 mM) and mexiletine (10(-3) to 10 mM) reduced oxidation of the mitochondrial matrix in a dose-dependent manner with an EC50 of 98+/-63 microM for lidocaine and 107+/-89 microM for mexiletine. Both lidocaine and mexiletine reduced flavoprotein fluorescence induced by diazoxide in rat ventricular myocytes, indicating that these antiarrhythmic drugs may produce impairment of mitochondrial oxidation mediated by mitochondrial K(ATP) channels.  (日)    [継承]
キーワード (推奨): 1. (英) Adenosine Triphosphate (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Anti-Arrhythmia Agents (日) (読) [継承]
4. (英) Calcium (日) (読) [継承]
5. (英) Diazoxide (日) (読) [継承]
6. (英) Heart Ventricles (日) (読) [継承]
7. (英) Lidocaine (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mexiletine (日) (読) [継承]
10. (英) Mitochondria, Heart (日) (読) [継承]
11. (英) Oxygen Consumption (日) (読) [継承]
12. (英) Potassium Channels (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Wistar (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 95 [継承]
(必須): 3 [継承]
(必須): 766 770 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 9月 初日 (平成 13年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1097/00000542-200109000-00032    (→Scopusで検索) [継承]
PMID (任意): 11575552    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000170872900028 [継承]
Scopus (任意): 2-s2.0-0034849904 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yasuo Tsutsumi, Shuzo Oshita, Takashi Kawano, Hiroshi Kitahata, Yoshinobu Tomiyama, Yasuhiro Kuroda and Yutaka Nakaya : Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes., Anesthesiology, Vol.95, No.3, 766-770, 2001.
欧文冊子 ● Yasuo Tsutsumi, Shuzo Oshita, Takashi Kawano, Hiroshi Kitahata, Yoshinobu Tomiyama, Yasuhiro Kuroda and Yutaka Nakaya : Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes., Anesthesiology, Vol.95, No.3, 766-770, 2001.

関連情報

Number of session users = 0, LA = 1.30, Max(EID) = 360929, Max(EOID) = 966657.