『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=90820EID:90820, Map:0, LastModified:2017年4月14日(金) 15:05:51, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[北畑 洋], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部.医学科.病態情報医学講座 [継承]
2.特殊栄養学講座 (〜2004年3月31日/->組織[徳島大学.医学部.医科栄養学科.臨床実践栄養学講座.代謝栄養学]) [継承]
著者 (必須): 1. (英) Kawano Takashi (日) 河野 崇 (読) かわの たかし
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2.大下 修造
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3. (英) Tsutsumi Yasuo (日) 堤 保夫 (読) つつみ やすお
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4.富山 芳信 ([徳島大学.病院.中央診療施設等.手術部])
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5.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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6. (英) Kuroda Yasuhiro (日) 黒田 泰弘 (読) くろだ やすひろ
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7.髙橋 章 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.予防環境栄養学])
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8.中屋 豊
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題名 (必須): (英) Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Activation of adenosine triphosphate-sensitive potassium (K(ATP)) channels produces cardioprotective effects during ischemia. Because propofol is often used in patients who have coronary artery disease undergoing a wide variety of surgical procedures, it is important to evaluate the direct effects of propofol on K(ATP) channel activities in ventricular myocardium during ischemia. The effects of propofol (0.4-60.1 microg/ml) on both sarcolemmal and mitochondrial K(ATP) channel activities were investigated in single, quiescent rat ventricular myocytes. Membrane currents were recorded using cell-attached and inside-out patch clamp configurations. Flavoprotein fluorescence was measured to evaluate mitochondrial oxidation mediated by mitochondrial K(ATP) channels. In the cell-attached configuration, open probability of K(ATP) channels was reduced by propofol in a concentration-dependent manner (EC(50) = 14.2 microg/ml). In the inside-out configurations, propofol inhibited K(ATP) channel activities without changing the single-channel conductance (EC(50) = 11.4 microg/ml). Propofol reduced mitochondrial oxidation in a concentration-dependent manner with an EC(50) of 14.6 microg/ml. Propofol had no effect on the sarcolemmal K(ATP) channel activities in patch clamp configurations and the mitochondrial flavoprotein fluorescence induced by diazoxide at clinically relevant concentrations (< 2 microm), whereas it significantly inhibited both K(ATP) channel activities at very high, nonclinical concentrations (> 5.6 microg/ml; 31 microm).  (日)    [継承]
キーワード (推奨): 1.アデノシン三リン酸 (adenosine triphosphate) [継承]
2. (英) Anesthetics, Intravenous (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Dose-Response Relationship, Drug (日) (読) [継承]
5.心臓 (heart) [継承]
6. (英) Heart Ventricles (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mitochondria, Heart (日) (読) [継承]
9. (英) Potassium Channels (日) (読) [継承]
10. (英) Propofol (日) (読) [継承]
11. (英) Rats (日) (読) [継承]
12. (英) Rats, Wistar (日) (読) [継承]
13. (英) Sarcolemma (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2002年 6月 初日 (平成 14年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1097/00000542-200206000-00029    (→Scopusで検索) [継承]
PMID (任意): 12170062    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000175965500028 [継承]
Scopus (任意): 2-s2.0-0036260435 [継承]
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指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan. bass@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Kawano, Shuzo Oshita, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda, Akira Takahashi and Yutaka Nakaya : Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes., Anesthesiology, Vol.96, No.6, 1472-1477, 2002.
欧文冊子 ● Takashi Kawano, Shuzo Oshita, Yasuo Tsutsumi, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda, Akira Takahashi and Yutaka Nakaya : Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes., Anesthesiology, Vol.96, No.6, 1472-1477, 2002.

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