| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.医学科.病態情報医学講座
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| 2. | 徳島大学.医学部.附属病院 (〜2003年9月30日/->組織[徳島大学.病院.医科診療部門])
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| ○著者 (必須): | 1. | 野﨑 淳平
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 北畑 洋
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| ○貢献度 (任意): |
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| 3. | 田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 大下 修造
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Effects of acute normovolemic hemodilution on ventriculoarterial coupling in dogs. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Acute normovolemic hemodilution (ANH) causes a decrease in systemic vascular resistance. Similar to vasodilating drugs, ANH might modify ventriculoarterial coupling. Left ventricular elastance (Ees), effective arterial elastance (Ea), stroke work (SW), and pressure volume area (PVA) were used as indicators to examine the effects of ANH on this coupling. After institutional approval eight dogs were anesthetized with isoflurane and subjected to measurements including aortic pressure, left ventricular (LV) pressure, and LV volume. Left ventricular volume was measured with a conductance catheter. Ees was determined as the slope of the end-systolic pressure-volume relationship. Ea was determined as the ratio of LV end-systolic pressure to stroke volume. Ventriculoarterial coupling was evaluated as the ratio of Ees to Ea. Mechanical efficiency, another criterion for ventriculoarterial coupling, was calculated as the ratio of SW to PVA. Data are expressed as mean+/-SD, and P<0.05 was considered significant. Normovolemic exchange of 50 ml kg-1 of blood for 6% hydroxyethyl starch (ANH50) reduced hemoglobin concentration from 12.8+/-3.0 g dl-1 to 6.4+/-1.3 g dl-1. Acute normovolemic hemodilution 50 did not change Ees significantly although it significantly decreased Ea. Left ventricular elastance/Ea did not change after ANH (1.0+/-0.4 at baseline and 1.2+/-0.5 at ANH50). Acute normovolemic hemodilution 50 significantly increased SW and PVA, preventing SW/PVA from changing significantly after ANH (0.57+/-0.10 at baseline and 0.62+/-0.14 at ANH50). Before ANH, ventriculoarterial coupling was so matched as to maximize SW at the expense of the work efficiency. This relation was preserved at ANH50. (日)
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| ○キーワード (推奨): | 1. | (英) Algorithms (日) (読)
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| 2. | (英) Anesthesia (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Arteries (日) (読)
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| 5. | (英) Blood Gas Analysis (日) (読)
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| 6. | (英) Blood Pressure (日) (読)
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| 7. | (英) Blood Volume (日) (読)
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| 8. | (英) Dogs (日) (読)
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| 9. | (英) Elasticity (日) (読)
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| 10. | (英) Female (日) (読)
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| 11. | (英) Heart (日) (読)
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| 12. | (英) Hemodilution (日) (読)
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| 13. | (英) Male (日) (読)
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| 14. | (英) Stroke Volume (日) (読)
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| 15. | (英) Ventricular Function (日) (読)
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| 16. | (英) Ventricular Function, Left (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Acta Anaesthesiologica Scandinavica (Nordisk anaestesiologisk forening/Scandinavian Society of Anaesthesiology and Intensive Care Medicine)
(pISSN: 0001-5172, eISSN: 1399-6576)
| ○ISSN (任意): | □ | 0001-5172
ISSN: 0001-5172
(pISSN: 0001-5172, eISSN: 1399-6576) Title: Acta anaesthesiologica ScandinavicaTitle(ISO): Acta Anaesthesiol ScandSupplier: Scandinavian Society of Anaesthesiology and Intensive Care MedicinePublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 47
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 46 52
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 1月 初日 (平成 15年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1034/j.1399-6576.2003.470108.x (→Scopusで検索)
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| ○PMID (任意): | □ | 12492796 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000179948400008
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Anesthesiology, Tokushima University School of Medicine, Japan. jnozaki@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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