| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.医学科.病態情報医学講座
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| 2. | 徳島大学.病院.診療科.脳·神経·精神科 (2003年10月1日〜)
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| 3. | 徳島大学.病院.中央診療施設等.手術部 (2003年10月1日〜)
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| ○著者 (必須): | 1. | 田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 北畑 洋
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 野﨑 淳平
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 富山 芳信 ([徳島大学.病院.中央診療施設等.手術部])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 6. | 大下 修造
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| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Phenylephrine increases pulmonary blood flow in children with tetralogy of Fallot. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Although it has been reported that the increase in blood pressure improves arterial oxygen saturation (SaO(2)) in children with tetralogy of Fallot, no prospective study has demonstrated that an increase in blood pressure induces an increase in pulmonary blood flow in these patients. The purpose of this study was to see whether a phenylephrine-induced increase in systemic blood pressure increased pulmonary blood flow, resulting in improved arterial oxygenation in tetralogy of Fallot. In 14 consecutive children with tetralogy of Fallot (2-32 months old), transesophageal pulsed Doppler signals of left upper pulmonary venous flow (PVF) velocity were recorded before and four minutes after 10 micro g x kg(-1) of phenylephrine i.v. Simultaneously, arterial blood gas analysis and hemodynamic measurements were performed. The minute distance (MD) was calculated as the product of the heart rate and the sum of time-velocity integrals of PVF. Phenylephrine iv increased mean arterial blood pressure from 54 +/- 8 mmHg to 73 +/- 10 mmHg. This phenylephrine-induced hypertension significantly increased SaO(2) and MD (92.0 +/- 7.5 vs 95.0 +/- 5.0% and 1318 +/- 344 vs 1533 +/- 425 cm x min(-1), respectively). There was a significant correlation (r = 0.72) between the change in MD and the change in SaO(2). Our results suggest that the phenylephrine-induced increase in systemic blood pressure produces an increase in pulmonary blood flow in tetralogy of Fallot. Our results further suggest that this increase in pulmonary blood flow is involved in the mechanism of phenylephrine-induced improvement of arterial oxygenation in tetralogy of Fallot. (日)
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| ○キーワード (推奨): | 1. | (英) Blood Flow Velocity (日) (読)
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| 2. | (英) Blood Gas Analysis (日) (読)
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| 3. | 子ども (children)
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| 4. | (英) Child, Preschool (日) (読)
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| 5. | (英) Echocardiography, Doppler, Pulsed (日) (読)
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| 6. | 経食道心エコー (transesophageal echocardiography)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Hemodynamics (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Hypertension (日) (読)
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| 11. | 小児 (infant)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Oxygen (日) (読)
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| 14. | (英) Phenylephrine (日) (読)
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| 15. | (英) Pulmonary Circulation (日) (読)
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| 16. | (英) Pulmonary Veins (日) (読)
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| 17. | (英) Tetralogy of Fallot (日) (読)
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| 18. | (英) Vasoconstrictor Agents (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Canadian Journal of Anaesthesia (Canadian Anesthesiologists' Society)
(pISSN: 0832-610X, eISSN: 1496-8975)
| ○ISSN (任意): | □ | 0832-610X
ISSN: 0832-610X
(pISSN: 0832-610X, eISSN: 1496-8975) Title: Canadian journal of anaesthesia = Journal canadien d'anesthesieTitle(ISO): Can J AnaesthPublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 50
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 926 929
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 11月 初日 (平成 15年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/BF03018741 (→Scopusで検索)
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| ○PMID (任意): | □ | 14617591 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000186862800012
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Anaesthesiology, Tokushima University School of Medicine, Tokushima, Japan. ktanaka@mcw.edu (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Clinical Trial (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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