『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=90695EID:90695, Map:0, LastModified:2017年11月30日(木) 21:18:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[北畑 洋], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部.医学科.病態情報医学講座 [継承]
著者 (必須): 1. (英) Masuda Takako (日) 増田 貴子 (読) ますだ たかこ
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2.富山 芳信 ([徳島大学.病院.中央診療施設等.手術部])
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3.北畑 洋 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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4. (英) Kuroda Yasuhiro (日) 黒田 泰弘 (読) くろだ やすひろ
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5.大下 修造
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題名 (必須): (英) Effect of propofol on hypotonic swelling-induced membrane depolarization in human coronary artery smooth muscle cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Stretch (mechanical stress)-induced membrane depolarization of smooth muscle may contribute to basal vascular tone and myogenic control. Propofol induces vasodilation and inhibits myogenic control. Hypotonic swelling was used as a model of mechanical stress. The authors investigated the effects of propofol and 5-nitro-2-(3-phenylpropylamino)benzoic acid, a chloride channel and nonselective cation channel blocker, on hypotonicity-induced membrane depolarization in cultured human coronary artery smooth muscle cells. A voltage-sensitive fluorescent dye, bis-(1,3-diethylthiobarbiturate)trimethine oxonol, was used to assess relative changes in membrane potential semiquantitatively. The cells were continuously perfused with Earle's balanced salt solution containing 200 nM bis-(1,3-diethylthiobarbiturate)trimethine oxonol and exposed sequentially to isotonic and hypotonic medium. In a second series of experiments, the cells were exposed to hypotonic media in the presence and absence of 5-nitro-2-(3-phenylpropylamino)benzoic acid or propofol. The relative fluorescence values at 10, 20, and 30% hypotonicity were 147 +/- 29, 214 +/- 74, and 335 +/- 102% of baseline, respectively. The changes were all significantly different from the isotonic time control group. In the presence of 200 microM 5-nitro-2-(3-phenylpropylamino)benzoic acid or 0.1, 1, 10, or 100 microg/ml propofol, the relative fluorescence values at 30% hypotonicity were 87 +/- 17, 194 +/- 27, 160 +/- 18, 130 +/- 18, and 84 +/- 15%, respectively. These changes were significantly less than the 30% for the hypotonic control (246 +/- 23%). These results suggest that volume-sensitive chloride channels and nonselective cation channels may participate in hypotonicity-induced membrane depolarization and that propofol inhibits hypotonicity-induced membrane depolarization in coronary artery smooth muscle.  (日)    [継承]
キーワード (推奨): 1. (英) Anesthetics, Intravenous (日) (読) [継承]
2. (英) Calibration (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Chloride Channels (日) (読) [継承]
5. (英) Coronary Vessels (日) (読) [継承]
6. (英) Fluorescent Dyes (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Hydrogen-Ion Concentration (日) (読) [継承]
9. (英) Hypotonic Solutions (日) (読) [継承]
10. (英) Ion Channels (日) (読) [継承]
11. (英) Membrane Potentials (日) (読) [継承]
12. (英) Muscle, Smooth, Vascular (日) (読) [継承]
13. (英) Nitrobenzoates (日) (読) [継承]
14. (英) Perfusion (日) (読) [継承]
15. (英) Potassium (日) (読) [継承]
16. (英) Propofol (日) (読) [継承]
17. (英) Sodium (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 648 656 [継承]
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年月日 (必須): 西暦 2004年 3月 初日 (平成 16年 3月 初日) [継承]
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DOI (任意): 10.1097/00000542-200403000-00027    (→Scopusで検索) [継承]
PMID (任意): 15108981    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, Tokushima University School of Medicine, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takako Masuda, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita : Effect of propofol on hypotonic swelling-induced membrane depolarization in human coronary artery smooth muscle cells., Anesthesiology, Vol.100, No.3, 648-656, 2004.
欧文冊子 ● Takako Masuda, Yoshinobu Tomiyama, Hiroshi Kitahata, Yasuhiro Kuroda and Shuzo Oshita : Effect of propofol on hypotonic swelling-induced membrane depolarization in human coronary artery smooth muscle cells., Anesthesiology, Vol.100, No.3, 648-656, 2004.

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