『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部.医学科 [継承]
著者 (必須): 1. (英) Kyaw Moe (日) モーチョー (読) もーちょー
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2.吉栖 正典
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3.土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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4.香美 祥二 ([徳島大学.病院])
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5.井澤 有紀 ([薬理学])
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6. (英) Fujita Yoshiko (日) 藤田 佳子 (読) ふじた よしこ
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7. (英) Ali Nermin (日) ネルミン アリ (読) ねるみん あり
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8.兼松 康久 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学]/[徳島大学.病院.中央診療施設等.地域脳神経外科診療部])
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9.樋田 一徳
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10.石村 和敬
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11.玉置 俊晃
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題名 (必須): (英) Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cell via extracellur signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation  (日)    [継承]
副題 (任意):
要約 (任意): (英) Angiotensin II (Ang II) plays an important role in several cardiovascular diseases associated with vascular smooth muscle cell (VSMC) growth and migration. Src activity is known to be required for the migration of a number of cell types. p130Cas was reported to be essential for cell migration and actin filament reorganization. Mitogen-activated protein (MAP) kinases were also reported to be critical regulatory factors for growth and migration of VSMC. However, precise intracellular mechanisms involving c-Src, p130Cas, and MAP kinases in Ang II-stimulated migration of VSMC have not been well elucidated. Here we demonstrated that Ang II rapidly and significantly stimulated tyrosine phosphorylation of Src and Cas and their association in rat aortic smooth muscle cells (RASMC). Ang II-stimulated tyrosine phosphorylation of Src and Cas and activation of ERK1/2 and JNK, but not p38, were potently inhibited by Src family tyrosine kinase inhibitors, herbimycin A (HA) and PP2. Ang II-stimulated Src and Cas association, tyrosine phosphorylation of Cas, and activation of ERK1/2 and JNK were suppressed in kinase-inactive Src (KI Src)-overexpressed RASMC. Ang II-stimulated JNK activation but not ERK1/2 activation was blocked in substrate domain-deleted Cas (DeltaSD Cas)-overexpressed RASMC. In addition, HA, PP2, ERK1/2 inhibitor, 2'-amino-3'-methoxyflavone (PD98059) and JNK inhibitor, and anthra[1,9-cd]pyrazol-6(2H)-one (SP600125) significantly inhibited Ang II-stimulated migration of RASMC. Ang II-induced colocalization of Src and Cas and migration were inhibited in both KI Src- and DeltaSD Cas-overexpressed RASMC. These findings suggest that Src and Cas are essentially but differentially involved in Ang II-stimulated migration of VSMC through the activation of ERK1/2 and JNK.  (日)    [継承]
キーワード (推奨): 1. (英) Angiotensin II (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Adhesion (日) (読) [継承]
4. (英) Cell Movement (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Cellular Apoptosis Susceptibility Protein (日) (読) [継承]
7. (英) Enzyme Activation (日) (読) [継承]
8. (英) Genes, src (日) (読) [継承]
9. (英) JNK Mitogen-Activated Protein Kinases (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mitogen-Activated Protein Kinase 3 (日) (読) [継承]
12. (英) Mitogen-Activated Protein Kinases (日) (読) [継承]
13. (英) Muscle, Smooth, Vascular (日) (読) [継承]
14.リン酸化 (phosphorylation) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Rats, Sprague-Dawley (日) (読) [継承]
17. (英) Tyrosine (日) (読) [継承]
18. (英) Vinculin (日) (読) [継承]
19. (英) src-Family Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Pharmacology (American Society for Pharmacology and Experimental Therapeutics)
(pISSN: 0026-895X, eISSN: 1521-0111)

ISSN (任意): 0026-895X
ISSN: 0026-895X (pISSN: 0026-895X, eISSN: 1521-0111)
Title: Molecular pharmacology
Title(ISO): Mol Pharmacol
Publisher: American Society for Pharmacology and Experimental Therapeutics
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 832 841 [継承]
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年月日 (必須): 西暦 2004年 4月 初日 (平成 16年 4月 初日) [継承]
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DOI (任意): 10.1124/mol.65.4.832    (→Scopusで検索) [継承]
PMID (任意): 15044612    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, The University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. yoshizu@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Moe Kyaw, Masanori Yoshizumi, Koichiro Tsuchiya, Shoji Kagami, Yuki Izawa, Yoshiko Fujita, Nermin Ali, Yasuhisa Kanematsu, Kazunori Toida, Kazunori Ishimura and Toshiaki Tamaki : Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cell via extracellur signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation, Molecular Pharmacology, Vol.65, No.4, 832-841, 2004.
欧文冊子 ● Moe Kyaw, Masanori Yoshizumi, Koichiro Tsuchiya, Shoji Kagami, Yuki Izawa, Yoshiko Fujita, Nermin Ali, Yasuhisa Kanematsu, Kazunori Toida, Kazunori Ishimura and Toshiaki Tamaki : Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cell via extracellur signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation, Molecular Pharmacology, Vol.65, No.4, 832-841, 2004.

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