| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yamamoto Yasuyo (日) (読)
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| 2. | 西村 範行
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| 3. | (英) Morimoto Shinya (日) (読)
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| 4. | (英) Kitamura Hiroko (日) (読)
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| 5. | (英) Manabe Shinji (日) (読)
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| 6. | 金山 博臣 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学])
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| 7. | 香川 征
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| 8. | 佐々木 卓也 ([徳島大学])
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| ○題名 (必須): | □ | (英) Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane (日)
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| ○要約 (任意): | □ | (英) Regulated transport of proteins to distinct plasma membrane domains is essential for the establishment and maintenance of cell polarity in all eukaryotic cells. The Rab family small G proteins play a crucial role in determining the specificity of vesicular transport pathways. Rab3B and Rab13 localize to tight junction in polarized epithelial cells and cytoplasmic vesicular structures in non-polarized fibroblasts, but their functions are poorly understood. Here we examined their roles in regulating the cell-surface transport of apical p75 neurotrophin receptor (p75NTR), basolateral low-density lipoprotein receptor (LDLR), and tight junctional Claudin-1 using transport assay in non-polarized fibroblasts. Overexpression of Rab3B mutants inhibited the cell-surface transport of LDLR, but not p75NTR and Claudin-1. In contrast, overexpression of Rab13 mutants impaired the transport of Claudin-1, but not LDLR and p75NTR. These results suggest that Rab3B and Rab13 direct the cell-surface transport of LDLR and Claudin-1, respectively, and may contribute to epithelial polarization. (日)
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| ○キーワード (推奨): | 1. | (英) Rab3B (日) (読)
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| 2. | (英) Rab13 (日) (読)
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| 3. | (英) Polarized transport (日) (読)
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| 4. | (英) Tight junction (日) (読)
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| 5. | (英) Claudins (日) (読)
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| ○発行所 (推奨): | □ | Elsevier (->組織[Elsevier Science])
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| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 0006-291X
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 308
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 270 275
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| ○年月日 (必須): | □ | 西暦 2003年 8月 22日 (平成 15年 8月 22日)
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| ○URL (任意): | □ | http://dx.doi.org/10.1016/S0006-291X(03)01358-5
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| ○DOI (任意): | □ | 10.1016/S0006-291X(03)01358-5 (→Scopusで検索)
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| ○PMID (任意): | □ | 12901864 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Biochemistry, The University of Tokushima, Graduate School of Medicine, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: In Vitro (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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