『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Yamamoto Yasuyo (日) (読)
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2.西村 範行
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3. (英) Morimoto Shinya (日) (読)
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4. (英) Kitamura Hiroko (日) (読)
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5. (英) Manabe Shinji (日) (読)
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6.金山 博臣 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学])
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7.香川 征
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8.佐々木 卓也 ([徳島大学])
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題名 (必須): (英) Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane  (日)    [継承]
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要約 (任意): (英) Regulated transport of proteins to distinct plasma membrane domains is essential for the establishment and maintenance of cell polarity in all eukaryotic cells. The Rab family small G proteins play a crucial role in determining the specificity of vesicular transport pathways. Rab3B and Rab13 localize to tight junction in polarized epithelial cells and cytoplasmic vesicular structures in non-polarized fibroblasts, but their functions are poorly understood. Here we examined their roles in regulating the cell-surface transport of apical p75 neurotrophin receptor (p75NTR), basolateral low-density lipoprotein receptor (LDLR), and tight junctional Claudin-1 using transport assay in non-polarized fibroblasts. Overexpression of Rab3B mutants inhibited the cell-surface transport of LDLR, but not p75NTR and Claudin-1. In contrast, overexpression of Rab13 mutants impaired the transport of Claudin-1, but not LDLR and p75NTR. These results suggest that Rab3B and Rab13 direct the cell-surface transport of LDLR and Claudin-1, respectively, and may contribute to epithelial polarization.  (日)    [継承]
キーワード (推奨): 1. (英) Rab3B (日) (読) [継承]
2. (英) Rab13 (日) (読) [継承]
3. (英) Polarized transport (日) (読) [継承]
4. (英) Tight junction (日) (読) [継承]
5. (英) Claudins (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2003年 8月 22日 (平成 15年 8月 22日) [継承]
URL (任意): http://dx.doi.org/10.1016/S0006-291X(03)01358-5 [継承]
DOI (任意): 10.1016/S0006-291X(03)01358-5    (→Scopusで検索) [継承]
PMID (任意): 12901864    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, The University of Tokushima, Graduate School of Medicine, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yasuyo Yamamoto, Noriyuki Nishimura, Shinya Morimoto, Hiroko Kitamura, Shinji Manabe, Hiro-omi Kanayama, Susumu Kagawa and Takuya Sasaki : Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane, Biochemical and Biophysical Research Communications, Vol.308, No.2, 270-275, 2003.
欧文冊子 ● Yasuyo Yamamoto, Noriyuki Nishimura, Shinya Morimoto, Hiroko Kitamura, Shinji Manabe, Hiro-omi Kanayama, Susumu Kagawa and Takuya Sasaki : Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane, Biochemical and Biophysical Research Communications, Vol.308, No.2, 270-275, 2003.

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