『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.徳島大学.医学部.医学科 [継承]
著者 (必須): 1. (英) Kirima Kazuyoshi (日) 桐間 一嘉 (読) きりま かずよし
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2.土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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3.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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4. (英) Hasegawa Toyoshi (日) 長谷川 豊司 (読) はせがわ とよし
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5. (英) Shikishima Michiyo (日) 敷島 紀代 (読) しきしま みちよ
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6. (英) Motobayashi Yuki (日) 元林 有紀 (読) もとばやし ゆき
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7.森田 恭二
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8.吉栖 正典
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9.玉置 俊晃
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題名 (必須): (英) Evaluatin of systemic blood NO dynamics by EPR Spectoscopy: HbNO as an endogenous index of NO  (日)    [継承]
副題 (任意):
要約 (任意): (英) The measurement of hemoglobin-nitric oxide (NO) adduct (HbNO) in whole blood by the electron paramagnetic resonance (EPR) method seems relevant for the assessment of systemic NO levels. However, ceruloplasmin and unknown radical species overlap the same magnetic field as that of HbNO. To reveal the EPR spectrum of HbNO, we then introduced the EPR signal subtraction method, which is based on the computer-assisted subtraction of the digitized EPR spectrum of HbNO-depleted blood from that of sample blood using the software. Rats were treated with N(omega)-nitro-L-arginine methyl ester (L-NAME; 120 mg. kg-1. day-1) for 1 wk to obtain HbNO-depleted blood. When this method was applied to the analysis of untreated fresh whole blood, the five-coordinate state of HbNO was observed. HbNO concentration in pentobarbital-anesthetized rats was augmented (change in [HbNO] = 1.6-5.5 microM) by infusion of L-arginine (0.2-0.6 g/kg) but not D-arginine. Using this method, we attempted to evaluate the effects of temocapril on HbNO dynamics in an L-NAME-induced rat endothelial dysfunction model. The oral administration of L-NAME for 2 wk induced a serious hypertension, and the HbNO concentration was reduced (change in [HbNO] = 5.7 microM). Coadministration of temocapril dose dependently improved both changes in blood pressure and the systemic HbNO concentration. In this study, we succeeded in measuring the blood HbNO level as an index of NO by the EPR HbNO signal subtraction method. We also demonstrated that temocapril improves abnormalities of NO dynamics in L-NAME-induced endothelial dysfunction rats using the EPR HbNO signal subtraction method.  (日)    [継承]
キーワード (推奨): 1. (英) Angiotensin-Converting Enzyme Inhibitors (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Arginine (日) (読) [継承]
4. (英) Calibration (日) (読) [継承]
5. (英) Electron Spin Resonance Spectroscopy (日) (読) [継承]
6. (英) Enzyme Inhibitors (日) (読) [継承]
7. (英) Hemoglobins (日) (読) [継承]
8. (英) Hypertension (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) NG-Nitroarginine Methyl Ester (日) (読) [継承]
11. (英) Nitric Oxide (日) (読) [継承]
12. (英) Rats (日) (読) [継承]
13. (英) Rats, Sprague-Dawley (日) (読) [継承]
14. (英) Thiazepines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology, Heart and Circulatory Physiology ([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)

ISSN (任意): 0363-6135
ISSN: 0363-6135 (pISSN: 0363-6135, eISSN: 1522-1539)
Title: American journal of physiology. Heart and circulatory physiology
Title(ISO): Am. J. Physiol. Heart Circ. Physiol.
Publisher: American Physiological Society
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(必須): 285 [継承]
(必須): 2 [継承]
(必須): H589 H596 [継承]
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年月日 (必須): 西暦 2003年 2月 初日 (平成 15年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1152/ajpheart.01010.2002    (→Scopusで検索) [継承]
PMID (任意): 12663263    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, The University of Tokushima School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuyoshi Kirima, Koichiro Tsuchiya, Hiroyoshi Sei, Toyoshi Hasegawa, Michiyo Shikishima, Yuki Motobayashi, Kyoji Morita, Masanori Yoshizumi and Toshiaki Tamaki : Evaluatin of systemic blood NO dynamics by EPR Spectoscopy: HbNO as an endogenous index of NO, American Journal of Physiology, Heart and Circulatory Physiology, Vol.285, No.2, H589-H596, 2003.
欧文冊子 ● Kazuyoshi Kirima, Koichiro Tsuchiya, Hiroyoshi Sei, Toyoshi Hasegawa, Michiyo Shikishima, Yuki Motobayashi, Kyoji Morita, Masanori Yoshizumi and Toshiaki Tamaki : Evaluatin of systemic blood NO dynamics by EPR Spectoscopy: HbNO as an endogenous index of NO, American Journal of Physiology, Heart and Circulatory Physiology, Vol.285, No.2, H589-H596, 2003.

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