『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=90382)

EID=90382EID:90382, Map:0, LastModified:2012年8月31日(金) 19:20:50, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.医学部.医学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.森田 恭二
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貢献度 (任意):
学籍番号 (推奨):
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2. (英) Wong Dona L. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
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題名 (必須): (英) Glucocorticoids enhance serum deprivation- but not calcium-induced cytotoxicity in rat C6 glioma cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) While glucocorticoids have been shown to exacerbate calcium-induced neuronal damage, little is known about the effects of these hormones on calcium-induced damage to glial cells. Here we examine the effect of synthetic glucocorticoid dexamethasone on calcium ionophore A23187 and serum deprivation-induced damage to rat C6 glioma cells. Treatment of the glioma cells with A23187 reduced cell viability, similar in extent to that observed with serum deprivation. Both A23187 and serum deprivation caused cell damage without degradation of the genomic DNA into nucleosomic fragments. In addition, the reduction in cell viability caused by A23187 was not significantly altered by DEX at concentrations enhancing serum deprivation-induced cell death. These results suggest that the cytotoxic effect of A23187 on glial cells may be mediated through a mechanism different from that underlying serum deprivation-induced cell death, and that, in contrast to calcium-induced neuronal damage, calcium-induced damage to glial cells is likely to be insensitive to glucocorticoids.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blood (日) (読) [継承]
3. (英) Calcimycin (日) (読) [継承]
4. (英) Calcium (日) (読) [継承]
5. (英) Cell Survival (日) (読) [継承]
6. (英) Culture Media (日) (読) [継承]
7. (英) Culture Media, Serum-Free (日) (読) [継承]
8. (英) DNA Fragmentation (日) (読) [継承]
9. (英) Dexamethasone (日) (読) [継承]
10. (英) Glioma (日) (読) [継承]
11. (英) Glucocorticoids (日) (読) [継承]
12. (英) Ionophores (日) (読) [継承]
13. (英) Neuroglia (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
15. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cell Biology International (International Federation for Cell Biology)
(pISSN: 1065-6995, eISSN: 1095-8355)

ISSN (任意): 1065-6995
ISSN: 1065-6995 (pISSN: 1065-6995, eISSN: 1095-8355)
Title: Cell biology international
Title(ISO): Cell Biol. Int.
Supplier: International Federation for Cell Biology
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 24 [継承]
(必須): 4 [継承]
(必須): 223 228 [継承]
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年月日 (必須): 西暦 2000年 4月 初日 (平成 12年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1006/cbir.1999.0494    (→Scopusで検索) [継承]
PMID (任意): 10816323    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, Tokushima University School of Medicine, Kuramoto, Tokushima, 770, Japan. m@basic.med.tikushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita and L. Dona Wong : Glucocorticoids enhance serum deprivation- but not calcium-induced cytotoxicity in rat C6 glioma cells, Cell Biology International, Vol.24, No.4, 223-228, 2000.
欧文冊子 ● Kyoji Morita and L. Dona Wong : Glucocorticoids enhance serum deprivation- but not calcium-induced cytotoxicity in rat C6 glioma cells, Cell Biology International, Vol.24, No.4, 223-228, 2000.

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