『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=90329EID:90329, Map:0, LastModified:2018年12月7日(金) 13:16:14, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨):
著者 (必須): 1.森田 恭二
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2. (英) Kuwada Aki (日) (読)
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3.藤原 広明
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4.森田 雄介
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5.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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題名 (必須): (英) Influence of sleep disturbance on steroid 5a-reductase mRNA levels in rat brain  (日)    [継承]
副題 (任意):
要約 (任意): (英) Sleep deprivation has been shown to affect the production of steroid hormones in peripheral steroidogenic organs, but little is known about the influence of sleep disturbance on the metabolism of steroid hormones in the brain. To elucidate a possible association of the sleep-wake cycle with brain neurosteroid metabolism, the influence of short-term sleep disturbance on the expression of mRNA encoding steroid 5alpha-reductase, the enzyme converting progesterone and other steroid hormones to their neuroactive 5alpha-reduced metabolites, was investigated. Rats were first subjected to non-selective disturbance of the sleep-wake cycle, and the expression of steroid 5alpha-reductase mRNA in rat hippocampus and brainstem was determined using a semi-quantitative one-step RT-PCR technique. Non-selective disturbance of the sleep-wake cycle resulted in the elevation of 5alpha-reductase mRNA levels in the brainstem, but not in the hippocampus, and the elevated mRNA expression returned to the basal levels after a short period of the sleep recovery. Further studies showed that selective REM sleep deprivation significantly elevated 5alpha-reductase mRNA levels in both hippocampus and brainstem, thus proposing the possibility that REM sleep reduction may largely contribute to the elevation of steroid 5alpha-reductase mRNA levels observed during short-term disturbance of the sleep-wake cycle. Since the enhancement of steroid 5alpha-reductase gene expression may result in the elevation of neuroactive 5alpha-reduced steroid production in the brainstem, the findings presented here provide further evidence for suggesting that neuroactive steroids may play a physiologically important role in the neuronal network for REM sleep initiation and maintenance.  (日)    [継承]
キーワード (推奨): 1. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Brain Stem (日) (読) [継承]
4. (英) Gene Expression Regulation, Enzymologic (日) (読) [継承]
5. (英) Hippocampus (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) RNA, Messenger (日) (読) [継承]
8. (英) Rats (日) (読) [継承]
9. (英) Rats, Wistar (日) (読) [継承]
10. (英) Sleep Deprivation (日) (読) [継承]
11. (英) Sleep, REM (日) (読) [継承]
12. (英) Steroids (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Neuroscience ([International Brain Research Organization])
(pISSN: 0306-4522, eISSN: 1873-7544)

ISSN (任意): 0306-4522
ISSN: 0306-4522 (pISSN: 0306-4522, eISSN: 1873-7544)
Title: Neuroscience
Title(ISO): Neuroscience
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 115 [継承]
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(必須): 341 348 [継承]
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年月日 (必須): 西暦 2002年 0月 初日 (平成 14年 0月 初日) [継承]
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DOI (任意): 10.1016/S0306-4522(02)00456-6    (→Scopusで検索) [継承]
PMID (任意): 12421601    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Neuroscience Group, Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Japan. km@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Aki Kuwada, Hiroaki Fujihara, Yusuke Morita and Hiroyoshi Sei : Influence of sleep disturbance on steroid 5a-reductase mRNA levels in rat brain, Neuroscience, Vol.115, No.2, 341-348, 2002.
欧文冊子 ● Kyoji Morita, Aki Kuwada, Hiroaki Fujihara, Yusuke Morita and Hiroyoshi Sei : Influence of sleep disturbance on steroid 5a-reductase mRNA levels in rat brain, Neuroscience, Vol.115, No.2, 341-348, 2002.

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