『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=90323EID:90323, Map:0, LastModified:2012年10月24日(水) 19:08:17, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨):
著者 (必須): 1.森田 恭二
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2. (英) Kuwada Aki (日) (読)
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3.藤原 広明
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4.森田 雄介
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5.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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題名 (必須): (英) Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation  (日)    [継承]
副題 (任意):
要約 (任意): (英) Selective REM sleep deprivation was carried out under the conditions designed to minimize the adverse influence of environmental conditions and restricted movement, and the influence of REM sleep deprivation on adrenocortical steroid metabolism was investigated by measuring the steady-state levels of mRNAs encoding steroid metabolism-related genes, steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme cytochrome P450 (P450scc) and steroid 5alpha-reductase (5alpha-R), in rat adrenal glands. Selective REM sleep deprivation caused a significant decrease in StAR mRNA and an increase in 5alpha-R mRNA levels without any notable change in P450scc mRNA levels in the adrenal gland. In contrast, non-selective sleep disturbance, resulting in the partial reductions of non-REM and REM sleep, tended to increase both StAR and P450scc mRNA levels without any statistical significance. These results indicate that REM sleep deprivation by itself may affect the expression of steroid metabolism-related genes in the adrenal gland, suggesting a possible relation between REM sleep and adrenocortical steroid metabolism.  (日)    [継承]
キーワード (推奨): 1. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (日) (読) [継承]
2. (英) Actins (日) (読) [継承]
3. (英) Adrenal Glands (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Cholesterol Side-Chain Cleavage Enzyme (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Phosphoproteins (日) (読) [継承]
9. (英) Polysomnography (日) (読) [継承]
10. (英) RNA, Messenger (日) (読) [継承]
11. (英) Rats (日) (読) [継承]
12. (英) Rats, Wistar (日) (読) [継承]
13. (英) Sleep Deprivation (日) (読) [継承]
14. (英) Sleep, REM (日) (読) [継承]
15. (英) Steroids (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Life Sciences ([Elsevier])
(pISSN: 0024-3205, eISSN: 1879-0631)

ISSN (任意): 0024-3205
ISSN: 0024-3205 (pISSN: 0024-3205, eISSN: 1879-0631)
Title: Life sciences
Title(ISO): Life Sci.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 72 [継承]
(必須): 17 [継承]
(必須): 1973 1982 [継承]
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年月日 (必須): 西暦 2003年 3月 14日 (平成 15年 3月 14日) [継承]
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DOI (任意): 10.1016/S0024-3205(03)00097-3    (→Scopusで検索) [継承]
PMID (任意): 12597996    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Neuroscience Group in Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Japan. km@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Aki Kuwada, Hiroaki Fujihara, Yusuke Morita and Hiroyoshi Sei : Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation, Life Sciences, Vol.72, No.17, 1973-1982, 2003.
欧文冊子 ● Kyoji Morita, Aki Kuwada, Hiroaki Fujihara, Yusuke Morita and Hiroyoshi Sei : Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation, Life Sciences, Vol.72, No.17, 1973-1982, 2003.

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