『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=90283EID:90283, Map:0, LastModified:2013年6月19日(水) 17:07:18, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.森田 恭二
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2.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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3.大西 克成
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題名 (必須): (英) In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: Induction of apoptotic cell death by extracellular pro-oxidant action  (日)    [継承]
副題 (任意):
要約 (任意): (英) Assessment of the in vitro cytotoxicity has recently been become popular as a primary screening method for evaluating the antitumor activities of various chemicals and natural substances. For example, quercetin and related phenolic compounds, present in teas, wines, and other plant products, have been shown to cause their cytotoxic effects on tumor cells in culture, proposing their protective effects against the development of cancer. However, 4-methylcatechol, a metabolite produced in the intestinal tract after ingestion, has been shown to cause the promotion rather than suppression of tumor in rat stomach despite its in vitro cytotoxic activity. To address the inconsistency between its in vivo and in vitro actions, the effect of 4-methylcatechol on the viabilities of murine tumor cells was examined, and 4-methylcatechol was shown to reduce their viabilities through the induction of apoptosis. In addition, since catechol compounds have been shown to have a complex mixture of pro-oxidant and antioxidant actions in the in vitro assay systems, the cytotoxic activity of 4-methylcatechol was reassessed in the presence of either catalase or reduced-form glutathione, and both of them were shown to protect the cells against the damage induced by 4-methylcatechol. Moreover, the generation of hydrogen peroxide was observed by incubating the drug in the growth medium with or without the cells. These findings indicate that, similar to other catechol compounds, 4-methylcatechol may induce the apoptotic death of murine tumor cells through its extracellular pro-oxidant action on the cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Apoptosis (日) (読) [継承]
3. (英) Catechols (日) (読) [継承]
4. (英) Cell Death (日) (読) [継承]
5. (英) Cell Survival (日) (読) [継承]
6. (英) Melanoma, Experimental (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Oxidants (日) (読) [継承]
9. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Pharmacology and Experimental Therapeutics (American Society for Pharmacology and Experimental Therapeutics)
(pISSN: 0022-3565, eISSN: 1521-0103)

ISSN (任意): 0022-3565
ISSN: 0022-3565 (pISSN: 0022-3565, eISSN: 1521-0103)
Title: The Journal of pharmacology and experimental therapeutics
Title(ISO): J. Pharmacol. Exp. Ther.
Publisher: American Society for Pharmacology and Experimental Therapeutics
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年月日 (必須): 西暦 2003年 4月 3日 (平成 15年 4月 3日) [継承]
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DOI (任意): 10.1124/jpet.103.050351    (→Scopusで検索) [継承]
PMID (任意): 12676882    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. km@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Hideki Arimochi and Yoshinari Ohnishi : In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: Induction of apoptotic cell death by extracellular pro-oxidant action, The Journal of Pharmacology and Experimental Therapeutics, Vol.306, No.1, 317-323, 2003.
欧文冊子 ● Kyoji Morita, Hideki Arimochi and Yoshinari Ohnishi : In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: Induction of apoptotic cell death by extracellular pro-oxidant action, The Journal of Pharmacology and Experimental Therapeutics, Vol.306, No.1, 317-323, 2003.

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