『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=90279EID:90279, Map:0, LastModified:2012年10月25日(木) 14:33:24, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
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著者 (必須): 1.藤原 広明
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2.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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3.森田 雄介
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4. (英) Ueta Yoichiro (日) (読)
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5.森田 恭二
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題名 (必須): (英) Short-term sleep disturbance enhances BDNF gene expression in rat hippocampus by acting as internal stressor  (日)    [継承]
副題 (任意):
要約 (任意): (英) Rats were subjected to nonselective sleep disturbance for short periods under conditions designed to minimize the adverse influence of external stresses, such as environmental conditions and restricted movement, and both brain-derived neurotrophic factor (BDNF) protein and its mRNA levels in the brain were then determined to investigate the influence of sleep disturbance itself on BDNF gene expression. Total sleep duration was partially but significantly reduced by disturbing the sleep/wake cycle for 1 and 2 h, gradually increased according to the time of disturbance, then returned to control levels at 6 h after the beginning of sleep disturbance. Under these conditions, the slight but significant elevation of corticotrophin-releasing factor (CRF) mRNA levels in the paraventricular nucleus (PVN) was observed at an early stage of the sleep disturbance period. Sleep disturbance induced the elevation of both BDNF protein and its mRNA levels in the hippocampus but not in the cerebellum or the brainstem, and the elevated BDNF mRNA expression in the hippocampus returned toward basal levels during the sleep recovery period when the rebound of sleep duration was observed. These findings suggest the possibility that short-term disturbance of the sleep/wake cycle and, hence, the partial reduction of non-REM sleep duration, might exert a potential influence on neuronal and/or glial cells as an internal stressor, resulting in the elevation of BDNF gene expression in rat hippocampus.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Brain-Derived Neurotrophic Factor (日) (読) [継承]
3. (英) Corticotropin-Releasing Hormone (日) (読) [継承]
4. (英) Hippocampus (日) (読) [継承]
5. (英) Hypothalamo-Hypophyseal System (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Paraventricular Hypothalamic Nucleus (日) (読) [継承]
8. (英) RNA, Messenger (日) (読) [継承]
9. (英) Rats (日) (読) [継承]
10. (英) Rats, Wistar (日) (読) [継承]
11. (英) Sleep Deprivation (日) (読) [継承]
12. (英) Sleep, REM (日) (読) [継承]
13. (英) Stress, Physiological (日) (読) [継承]
14. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Molecular Neuroscience : MN ([Springer-Verlag])
(pISSN: 0895-8696, eISSN: 1559-1166)

ISSN (任意): 0895-8696
ISSN: 0895-8696 (pISSN: 0895-8696, eISSN: 1559-1166)
Title: Journal of molecular neuroscience : MN
Title(ISO): J. Mol. Neurosci.
Supplier: Springer Online Journal Archive
Publisher: Springer New York
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(必須): 223 232 [継承]
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年月日 (必須): 西暦 2003年 0月 初日 (平成 15年 0月 初日) [継承]
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DOI (任意): 10.1385/JMN:21:3:223    (→Scopusで検索) [継承]
PMID (任意): 14645989    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Integrative Physiology, Tokushima University School of Medicine, Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroaki Fujihara, Hiroyoshi Sei, Yusuke Morita, Yoichiro Ueta and Kyoji Morita : Short-term sleep disturbance enhances BDNF gene expression in rat hippocampus by acting as internal stressor, Journal of Molecular Neuroscience : MN, Vol.21, No.3, 223-232, 2003.
欧文冊子 ● Hiroaki Fujihara, Hiroyoshi Sei, Yusuke Morita, Yoichiro Ueta and Kyoji Morita : Short-term sleep disturbance enhances BDNF gene expression in rat hippocampus by acting as internal stressor, Journal of Molecular Neuroscience : MN, Vol.21, No.3, 223-232, 2003.

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