『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=90267EID:90267, Map:0, LastModified:2014年4月16日(水) 15:50:22, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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著者 (必須): 1.森田 恭二
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2.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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3. (英) Tsuruo Yoshihiro (日) 鶴尾 吉宏 (読)
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題名 (必須): (英) Adrenergic activation of steroid 5a-reductase gene expression in rat C6 glioma cells: Involvement of cyclic AMP/protein kinase A-mediated signaling pathway  (日)    [継承]
副題 (任意):
要約 (任意): (英) Steroid 5alpha-reductase (5alpha-R) is well known as the enzyme converting progesterone and other steroid hormones to their 5alpha-reduced metabolites and has been reported to be localized in both neuronal and glial cells in the brain. Previously, the enzyme activity in glial cells has been shown to be enhanced either by coculturing with neuronal cells or by adding the conditioned medium of neuronal cells, suggesting a possible implication of neuro-glial interactions in the regulation of neurosteroid metabolism in the brain. In the present studies, the effects of adrenergic agonists on 5alpha-R mRNA and protein levels in rat C6 glioma cells were examined as one of the model experiments for investigating the influence of neuronal activity on the expression of 5alpha-R gene in the glial cell. The direct challenge of beta-adrenergic agonists to glioma cells resulted in the rapid and transient elevation of 5alpha-R mRNA levels through the activation of the cyclic AMP (cAMP)/protein kinase A-mediated signaling pathway. Further studies showed that cAMP-induced 5alpha-R mRNA expression was completely abolished by pretreatment of cells with actinomycin D and also indicated that the elevation of 5alpha-R mRNA levels was accompanied by an increase in enzyme protein in the cells. These findings provide strong evidence that the stimulation of beta-adrenergic receptors might induce the transcriptional activation of 5alpha-R gene expression in glial cells, proposing the possibility that neuronal activity might be involved in the production of neuroactive 5alpha-reduced steroids in the brain.  (日)    [継承]
キーワード (推奨): 1. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (日) (読) [継承]
2. (英) Adrenergic beta-Agonists (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Catecholamines (日) (読) [継承]
5. (英) Cell Communication (日) (読) [継承]
6. (英) Cyclic AMP (日) (読) [継承]
7. (英) Cyclic AMP-Dependent Protein Kinases (日) (読) [継承]
8. (英) Dactinomycin (日) (読) [継承]
9. (英) Gene Expression Regulation, Enzymologic (日) (読) [継承]
10. (英) Glioma (日) (読) [継承]
11. (英) Neuroglia (日) (読) [継承]
12. (英) Neurons (日) (読) [継承]
13. (英) RNA, Messenger (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
15. (英) Receptors, Adrenergic, beta (日) (読) [継承]
16. (英) Steroids (日) (読) [継承]
17. (英) Transcriptional Activation (日) (読) [継承]
18. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Molecular Neuroscience : MN ([Springer-Verlag])
(pISSN: 0895-8696, eISSN: 1559-1166)

ISSN (任意): 0895-8696
ISSN: 0895-8696 (pISSN: 0895-8696, eISSN: 1559-1166)
Title: Journal of molecular neuroscience : MN
Title(ISO): J. Mol. Neurosci.
Supplier: Springer Online Journal Archive
Publisher: Springer New York
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 22 [継承]
(必須): 3 [継承]
(必須): 205 212 [継承]
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年月日 (必須): 西暦 2004年 0月 初日 (平成 16年 0月 初日) [継承]
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DOI (任意): 10.1385/JMN:22:3:205    (→Scopusで検索) [継承]
PMID (任意): 14997014    (→Scopusで検索) [継承]
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WOS (任意): 000220312300006 [継承]
Scopus (任意): 2-s2.0-2942544169 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, Tokushima University Schoolof Medicine, Kuramoto, Tokushima 770-8503, Japan. km@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Hideki Arimochi and Yoshihiro Tsuruo : Adrenergic activation of steroid 5a-reductase gene expression in rat C6 glioma cells: Involvement of cyclic AMP/protein kinase A-mediated signaling pathway, Journal of Molecular Neuroscience : MN, Vol.22, No.3, 205-212, 2004.
欧文冊子 ● Kyoji Morita, Hideki Arimochi and Yoshihiro Tsuruo : Adrenergic activation of steroid 5a-reductase gene expression in rat C6 glioma cells: Involvement of cyclic AMP/protein kinase A-mediated signaling pathway, Journal of Molecular Neuroscience : MN, Vol.22, No.3, 205-212, 2004.

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