『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
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組織 (推奨):
著者 (必須): 1.後藤田 貴子
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2. (英) Kuwada Aki (日) (読)
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3.森田 恭二
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4.久保 真一
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5.徳永 逸夫
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題名 (必須): (英) Elevation of steroid 5 α-reductase mRNA levels in rat cerebellum by toluene inhalation: possible relation to GFAP expression  (日)    [継承]
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要約 (任意): (英) Toluene, a commonly used industrial solvent, is known to be toxic to both neuronal and glial cells, and has been shown to increase the immunoreactivity of glial fibrillary acidic protein (GFAP) in the brain. However, the mechanism of toluene-induced GFAP expression is poorly understood. Recently, GFAP mRNA expression in cultured astrocytes has been shown to be modulated by various steroid hormones, such as progesterone, testosterone, and their 5 alpha-reduced metabolites. Therefore, it seems possible that steroid hormones may play a potential role in the enhancement of GFAP expression observed following toluene exposure. To address this possibility, the effect of toluene inhalation on the expression of mRNAs encoding GFAP and steroidogenic enzymes in rat brain was examined. Toluene exposure increased GFAP protein contents without any significant alteration in GFAP mRNA levels in the hippocampus. In contrast, the elevation of both GFAP protein contents and its mRNA levels was observed in the cerebellum following toluene exposure. Further studies indicated that toluene exposure increased steroid 5 alpha-reductase (5 alpha-R) mRNA levels prior to the elevation of GFAP mRNA in the cerebellum, whereas neither 5 alpha-R nor GFAP mRNA levels in the hippocampus were significantly affected by toluene exposure. These results suggest that toluene inhalation may enhance GFAP gene expression in the rat cerebellum, and propose the possibility that the elevation of 5 alpha-R expression, and hence 5 alpha-reduced metabolites of steroid hormones, is presumably related to toluene-induced GFAP mRNA expression.  (日)    [継承]
キーワード (推奨): 1. (英) 3-Hydroxysteroid Dehydrogenases (日) (読) [継承]
2. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (日) (読) [継承]
3. (英) Administration, Inhalation (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5.小脳 (cerebellum) [継承]
6. (英) Cholesterol Side-Chain Cleavage Enzyme (日) (読) [継承]
7. (英) Enzyme Induction (日) (読) [継承]
8. (英) Gene Expression Regulation, Enzymologic (日) (読) [継承]
9. (英) Glial Fibrillary Acidic Protein (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Oligonucleotides (日) (読) [継承]
12. (英) RNA, Messenger (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Wistar (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
16. (英) Toluene (日) (読) [継承]
発行所 (推奨): (英) The Japanese Society of Toxicology (日) 日本毒性学会 (読) にほんどくせいがっかい [継承]
誌名 (必須): The Journal of Toxicological Sciences (日本トキシコロジー学会)
(pISSN: 0388-1350, eISSN: 1880-3989)

ISSN (任意): 0388-1350
ISSN: 0388-1350 (pISSN: 0388-1350, eISSN: 1880-3989)
Title: The Journal of toxicological sciences
Title(ISO): J Toxicol Sci
Supplier: 日本毒性学会
Publisher: Japanese Society of Toxicological Sciences
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 25 [継承]
(必須): 3 [継承]
(必須): 223 231 [継承]
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年月日 (必須): 西暦 2000年 8月 17日 (平成 12年 8月 17日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/110001806639/ [継承]
DOI (任意): 10.2131/jts.25.3_223    (→Scopusで検索) [継承]
PMID (任意): 10987130    (→Scopusで検索) [継承]
NAID (任意): 110001806639 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takako Gotohda, Aki Kuwada, Kyoji Morita, Shin-ichi Kubo and Itsuo Tokunaga : Elevation of steroid 5 α-reductase mRNA levels in rat cerebellum by toluene inhalation: possible relation to GFAP expression, The Journal of Toxicological Sciences, Vol.25, No.3, 223-231, 2000.
欧文冊子 ● Takako Gotohda, Aki Kuwada, Kyoji Morita, Shin-ichi Kubo and Itsuo Tokunaga : Elevation of steroid 5 α-reductase mRNA levels in rat cerebellum by toluene inhalation: possible relation to GFAP expression, The Journal of Toxicological Sciences, Vol.25, No.3, 223-231, 2000.

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