『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.後藤田 貴子
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2.徳永 逸夫
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3.久保 真一
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4.森田 恭二
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5.北村 修
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6. (英) Eguchi Akiko (日) 江口 安希子 (読) えぐち あきこ
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題名 (必須): (英) Effect of toluene inhalation on astrocytes and neurotrophic factor in rat brain  (日)    [継承]
副題 (任意):
要約 (任意): (英) Toluene, an abused substance in Japan, is a neurotoxic chemical that has been shown to have neurobehavioral and electrophysiological effects. In previous work, both acute and chronic effects of toluene on cells have been studied extensively. However, although glial cells are thought to play an important role in the survival of neurons in the brain, the effect of toluene on glial cell function has not yet been characterized. To elucidate this, the effect of toluene inhalation on astrocytes in rat brain was examined. Toluene exposure (1500 ppm for 4 h on 4-10 days) augmented glial fibrillary acidic protein (GFAP) immunoreactivity, particularly in the hippocampus and cerebellum. Quantitative analysis showed that toluene inhalation markedly enhanced GFAP expression in the hippocampus and cerebellum. In both regions, proliferating cell nuclear antigen (PCNA) showed no obvious changes, but glutamine synthetase (GS)-immunoreactive cells were markedly increased by toluene exposure. Thus, the elevation of GFAP expression was induced by astrocyte activation rather than by cell proliferation. If toluene exposure activates astrocytes, astrocytes may play a role in the neurophysiological changes observed in toluene intoxication. A neurotrophic factor, basic fibroblast growth factor (b-FGF) was observed immunohistochemically in the capillary vessel walls in the hippocampus and the cerebellum of toluene-intoxicated rats. Basic-FGF may have induced GFAP expression both in the hippocampus and the cerebellum. So, other neurotrophic factors may affect the difference of GFAP elevation between the hippocampus and the cerebellum. These differences may relate to neurobehavioral function of each brain part after toluene exposure.  (日)    [継承]
キーワード (推奨): 1. (英) Acute Disease (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Astrocytes (日) (読) [継承]
4. (brain) [継承]
5. (英) Brain Chemistry (日) (読) [継承]
6. (英) Chronic Disease (日) (読) [継承]
7. (英) Disease Models, Animal (日) (読) [継承]
8. (英) Glial Fibrillary Acidic Protein (日) (読) [継承]
9. (英) Glutamate-Ammonia Ligase (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Inhalation Exposure (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Nerve Growth Factors (日) (読) [継承]
14. (英) Proliferating Cell Nuclear Antigen (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Rats, Wistar (日) (読) [継承]
17. (英) Substance-Related Disorders (日) (読) [継承]
18. (英) Time Factors (日) (読) [継承]
19. (英) Toluene (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Forensic Science International ([Elsevier])
(pISSN: 0379-0738, eISSN: 1872-6283)

ISSN (任意): 0379-0738
ISSN: 0379-0738 (pISSN: 0379-0738, eISSN: 1872-6283)
Title: Forensic science international
Title(ISO): Forensic Sci. Int.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 233 238 [継承]
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年月日 (必須): 西暦 2000年 9月 11日 (平成 12年 9月 11日) [継承]
URL (任意):
DOI (任意): 10.1016/S0379-0738(00)00215-2    (→Scopusで検索) [継承]
PMID (任意): 10978631    (→Scopusで検索) [継承]
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WOS (任意): 000089534800041 [継承]
Scopus (任意): 2-s2.0-0343006762 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takako Gotohda, Itsuo Tokunaga, Shin-ichi Kubo, Kyoji Morita, Osamu Kitamura and Akiko Eguchi : Effect of toluene inhalation on astrocytes and neurotrophic factor in rat brain, Forensic Science International, Vol.113, No.1-3, 233-238, 2000.
欧文冊子 ● Takako Gotohda, Itsuo Tokunaga, Shin-ichi Kubo, Kyoji Morita, Osamu Kitamura and Akiko Eguchi : Effect of toluene inhalation on astrocytes and neurotrophic factor in rat brain, Forensic Science International, Vol.113, No.1-3, 233-238, 2000.

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