『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨):
著者 (必須): 1.伊藤 美紀子
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2. (英) Iidawa Sachi (日) 飯田和 祥 (読)
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3. (英) Izuka Michiyo (日) 猪塚 倫代 (読)
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4. (英) Haito Sakiko (日) 拝藤 紗貴子 (読)
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5.瀬川 博子 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.応用栄養学])
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6.桑波田 雅士
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7. (英) Ohkido Ichiro (日) 大城戸 一郎 (読)
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8. (英) Ohno Hiroshi (日) 大野 博 (読)
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9.宮本 賢一
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題名 (必須): (英) Interaction of a farnesylated protein with rwnal type a Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Treatment with PTH (parathyroid hormone) or a high-P(i) diet causes internalization of the type IIa sodium-dependent phosphate (Na/P(i) IIa) co-transporter from the apical membrane and its degradation in the lysosome. A dibasic amino acid motif (KR) in the third intracellular loop of the co-transporter is essential for protein's PTH-induced retrieval. To elucidate the mechanism of internalization of Na/P(i) IIa, we identified the interacting protein for the endocytic motif by yeast two-hybrid screening. We found a strong interaction of the Na/P(i) IIa co-transporter with a small protein known as the PEX19 (human peroxisomal farnesylated protein; PxF, Pex19p). PEX19 can bind to the KR motif, but not to a mutant with this motif replaced with NI residues. PEX19 is highly expressed in mouse and rat kidney. Western blot analysis indicates that PEX19 is located in the cytosolic and brush-border membrane fractions (microvilli and the subapical component). Overexpression of PEX19 stimulated the endocytosis of the Na/P(i) IIa co-transporter in opossum kidney cells in the absence of PTH. In conclusion, the present study indicates that PEX19 may be actively involved in controlling the internalization and trafficking of the Na/P(i) IIa co-transporter.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Down-Regulation (日) (読) [継承]
5. (英) Gene Library (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Kidney (日) (読) [継承]
8. (英) Kidney Tubules, Proximal (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Membrane Proteins (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Microvilli (日) (読) [継承]
13. (英) Molecular Sequence Data (日) (読) [継承]
14. (英) Opossums (日) (読) [継承]
15. (英) Parathyroid Hormone (日) (読) [継承]
16. (英) Peptides (日) (読) [継承]
17. (英) Phosphates (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Rats, Wistar (日) (読) [継承]
20.シグナル伝達 (signal transduction) [継承]
21. (英) Sodium-Phosphate Cotransporter Proteins (日) (読) [継承]
22. (英) Sodium-Phosphate Cotransporter Proteins, Type IIa (日) (読) [継承]
23. (英) Symporters (日) (読) [継承]
24. (英) Transfection (日) (読) [継承]
25. (英) Two-Hybrid System Techniques (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 1470-8728
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 377 [継承]
(必須): 3 [継承]
(必須): 607 616 [継承]
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年月日 (必須): 西暦 2004年 2月 1日 (平成 16年 2月 1日) [継承]
URL (任意):
DOI (任意): 10.1042/BJ20031223    (→Scopusで検索) [継承]
PMID (任意): 14558883    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Nutrition, Tokushima University, School of Medicine, Kuramoto-cho 3-18-15, Tokushima City 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1223893  (日)    [継承]

標準的な表示

和文冊子 ● Mikiko Ito, Sachi Iidawa, Michiyo Izuka, Sakiko Haito, Hiroko Segawa, Masashi Kuwahata, Ichiro Ohkido, Hiroshi Ohno and Ken-ichi Miyamoto : Interaction of a farnesylated protein with rwnal type a Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate., The Biochemical Journal, Vol.377, No.3, 607-616, 2004.
欧文冊子 ● Mikiko Ito, Sachi Iidawa, Michiyo Izuka, Sakiko Haito, Hiroko Segawa, Masashi Kuwahata, Ichiro Ohkido, Hiroshi Ohno and Ken-ichi Miyamoto : Interaction of a farnesylated protein with rwnal type a Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate., The Biochemical Journal, Vol.377, No.3, 607-616, 2004.

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