| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 瀬川 博子 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.応用栄養学])
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| 2. | (英) Kawakami Eri (日) 川上 絵里 (読)
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| 3. | 金子 一郎
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| 4. | 桑波田 雅士
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| 5. | 伊藤 美紀子
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| 6. | (英) Kusano Kenichiro (日) 草野 健一郎 (読)
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| ○学籍番号 (推奨): |
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| 7. | (英) Saito Hitoshi (日) 斉藤 仁 (読)
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| 8. | (英) Fukushima Naoshi (日) 福島 直 (読)
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| 9. | 宮本 賢一
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| ○題名 (必須): | □ | (英) Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Fibroblast growth factor 23 (FGF23), a phosphaturic factor, is involved in the regulation of renal inorganic phosphate (Pi) reabsorption. Proteolysis-resistant FGF23 mutants expressed in rodents reduce Pi uptake in both intestine and kidney, independent of parathyroid hormone action. In the present study, we investigated whether FGF23 affects dietary regulation of Na(+)-dependent Pi (Na/Pi) cotransport in the rat kidney using wild-type FGF23 and an R179Q mutant, which disrupts a consensus proteolytic cleavage motif. Rats injected with naked human FGF23 DNA (wild-type or R179Q mutant) expressed the human FGF23 transcript in the liver. In those animals, plasma calcium and parathyroid hormone levels were not affected by FGF23 (either wild-type or R179Q mutant). FGF23-R179Q did, however, significantly decrease plasma Pi and renal Na/Pi cotransport activity and also the level of type-IIc Na/Pi cotransporter protein in brush-border membrane vesicles (BBMVs) from normal rat kidney. Western blot and immunohistochemical analyses in rats fed a low-Pi diet showed the levels of types-IIa and -IIc Na/Pi cotransporters to be markedly increased. After injection of FGF23-R179Q DNA into the rats fed a low-Pi diet, the levels of the types-IIa and -IIc transporter proteins were decreased. The FGF23 mutant thus blunts the signalling of Pi deprivation to the renal type-II Na/Pi cotransporter, suggesting that the FGF23 pathway could be involved in the signalling of dietary Pi. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | カルシウム (calcium)
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| 3. | (英) Fibroblast Growth Factors (日) (読)
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| 4. | 遺伝子発現 (gene expression)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Hydrolysis (日) (読)
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| 7. | 免疫組織化学 (immunohistochemistry)
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| 8. | (英) Kidney Tubules, Proximal (日) (読)
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| 9. | (英) Male (日) (読)
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| 10. | (英) Mutagenesis, Site-Directed (日) (読)
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| 11. | (英) Parathyroid Hormone (日) (読)
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| 12. | (英) Phosphates (日) (読)
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| 13. | (英) Phosphorus, Dietary (日) (読)
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| 14. | (英) RNA, Messenger (日) (読)
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| 15. | (英) Rats (日) (読)
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| 16. | (英) Rats, Wistar (日) (読)
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| 17. | シグナル伝達 (signal transduction)
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| 18. | (英) Sodium (日) (読)
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| 19. | (英) Sodium-Phosphate Cotransporter Proteins (日) (読)
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| 20. | (英) Sodium-Phosphate Cotransporter Proteins, Type II (日) (読)
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| 21. | (英) Symporters (日) (読)
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| 22. | (英) Vitamin D (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Pflügers Archiv : European Journal of Physiology ([Springer-Verlag])
(pISSN: 0031-6768, eISSN: 1432-2013)
| ○ISSN (任意): | □ | 0031-6768
ISSN: 0031-6768
(pISSN: 0031-6768, eISSN: 1432-2013) Title: Pflugers Archiv : European journal of physiologyTitle(ISO): Pflugers ArchSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 446
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 585 592
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 7月 8日 (平成 15年 7月 8日)
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| ○URL (任意): | □ | http://www.springerlink.com/content/8t7dbaktcwm059eu/
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| ○DOI (任意): | □ | 10.1007/s00424-003-1084-1 (→Scopusで検索)
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| ○PMID (任意): | □ | 12851820 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000184762100012
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Kuramoto-cho 3, 770-8503 Tokushima City, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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