『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=89339EID:89339, Map:0, LastModified:2013年1月23日(水) 14:09:27, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[佐藤 陽一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.柴田 洋文
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2. (英) Shirakata Chikako (日) (読)
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3. (英) Kawasaki Hiromi (日) (読)
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4.佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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5.桑原 知巳
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6.大西 克成
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7.新垣 尚捷
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8.樋口 富彦
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題名 (必須): (英) Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically.  (日)    [継承]
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要約 (任意): (英) Flavone and its derivatives had very weak antibacterial effects on niethicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus, but dramatically intensified MRSA's susceptibility to β-lactams. We named these compounds "ILSMR (intensifier of β-lactam-susceptibility in MRSA)." We also found discrepancies among MRSA strains in their responses to flavone; some strains showed phenotypic susceptibility to methicillin while others showed phenotypic resistance to it. To understand the mechanism underlying this discrepancy, we characterized 20 MRSA strains in detail, analyzed their conventional and molecular typings, and examined each strain's resistance to β-lactams, with COL serving as a reference. Neither SCCmec typing nor coagulase typing explained the diverse effects of flavone on the β-lactam MICs of these strains. Likewise, changes in pulsed-field gel electrophoresis (PFGE) type were not associated with the profiles of ILSMR effects. However, the present observations suggest that the ILSMR effects on MRSA is strain-specific, and that this effect depends on an as-yet unknown mechanism that is essential for the expression of the phenotype conferring β-lactam resistance to MRSA strains, independently of an interaction with the mecA-encoded penicillin-binding protein 2a or with the β-lactamase.  (日)    [継承]
キーワード (推奨): 1. (英) methicillin-resistant Staphvlococcus aureus (MRSA) (日) (読) [継承]
2. (英) flavone (日) (読) [継承]
3. (英) β-lactam-resistance (日) (読) [継承]
4. (英) SCCmec (日) (読) [継承]
5. (英) population analysis (日) (読) [継承]
6. (英) minimum inhibitory concentration (MIC) (日) (読) [継承]
発行所 (推奨): (英) The Pharmaceutical Society of Japan (日) 公益社団法人日本薬学会 (読) [継承]
誌名 (必須): Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)

ISSN (任意): 0918-6158
ISSN: 0918-6158 (pISSN: 0918-6158, eISSN: 1347-5215)
Title: Biological & pharmaceutical bulletin
Title(ISO): Biol Pharm Bull
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 26 [継承]
(必須): 10 [継承]
(必須): 1478 1483 [継承]
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年月日 (必須): 西暦 2003年 10月 1日 (平成 15年 10月 1日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/110003608328/ [継承]
DOI (任意): 10.1248/bpb.26.1478    (→Scopusで検索) [継承]
PMID (任意): 14519958    (→Scopusで検索) [継承]
NAID (任意): 110003608328 [継承]
WOS (任意): 000185771500021 [継承]
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和文冊子 ● Hirofumi Shibata, Chikako Shirakata, Hiromi Kawasaki, Youichi Sato, Tomomi Kuwahara, Yoshinari Ohnishi, Naokatu Arakaki and Tomihiko Higuti : Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically., Biological & Pharmaceutical Bulletin, Vol.26, No.10, 1478-1483, 2003.
欧文冊子 ● Hirofumi Shibata, Chikako Shirakata, Hiromi Kawasaki, Youichi Sato, Tomomi Kuwahara, Yoshinari Ohnishi, Naokatu Arakaki and Tomihiko Higuti : Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically., Biological & Pharmaceutical Bulletin, Vol.26, No.10, 1478-1483, 2003.

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